丹参酮ⅡA磺酸钠联合西药治疗不稳定型心绞痛疗效的meta分析

Meta-analysis of Effect of Sodium TanshinoneⅡA Sulfonate Combined with Western Medicine in Treating Unstable Angina Pectoris

目的初步评价丹参酮ⅡA磺酸钠注射液治疗不稳定型心绞痛的疗效和安全性。方法计算机检索国内外公开发表的关于丹参酮ⅡA磺酸钠注射液治疗不稳定型心绞痛的随机对照试验,使用改良版Jadad评分法进行质量评价,采用RevMan5.3软件进行各结局指标的meta分析。结果共纳入27项研究进行meta分析,显示在治疗不稳定性心绞痛的总有效率、心电图改善率及血浆黏度改善方面,丹参酮ⅡA磺酸钠注射液治疗组均优于常规治疗组。结论基于当前证据,常规治疗加用丹参酮ⅡA磺酸钠注射液在治疗不稳定型心绞痛能取得更优的临床疗效,且不良反应发生率低。

OBJECTIVE To evaluate the efficacy and safety of sodium tanshinoneⅡA sulfonate injection in the treatment of unstable angina pectoris.METHODS Randomized controlled trials of sodium tanshinoneⅡA sulfonate injection for the treatment of unstable angina pectoris were performed with the database by computer,used modified Jadad scoring method for quality evaluation and used Revman5.3 for meta-analysis for each outcome.RESULTS A total of 27 studies of meta-analysis showed that the total effective rate of unstable angina pectoris,ECG improvement rate and plasma viscosity improvement in the treatment group of sodium tanshinoneⅡA sulfonate injection were superior to conventional treatment group.CONCLUSION Based on the current evidence,adjuvant therapy of sodium tanshinoneⅡA sulfonate injection can achieve better clinical efficacy in the treatment of unstable angina pectoris,with low adverse reactions rate.