川崎病患儿冠状动脉病变的危险因素调查

Investigation on risk factors of children Kawasaki disease complication with coronary artery lesion

目的探讨川崎病患儿冠状动脉病变的发生率及其危险因素。方法回顾性调查283例川崎病患儿,根据其是否发生冠状动脉病变将其分为冠状动脉病变组和无冠状动脉病变组;分析川崎病患儿的冠状动脉病变发生率,采用χ^2检验和多因素logistic回归法筛选川崎病患儿冠状动脉病变发生的高危因素。结果283例住院川崎病患儿中冠状动脉病变发生率为31.10%;影响川崎病患儿冠状动脉病变发生的危险因素包括发热时间(OR=2.818)、延迟诊治(OR=3.459)、hs-CRP(OR=3.815)、血沉(OR=4.031)、cTnI(OR=5.618)、IVIG抵抗(OR=4.618)等。结论川崎病患儿具有较高的冠状动脉病变发生率,应针对以上高危因素,早期进行筛查、诊断和治疗,降低冠状动脉病变的发生率,改善川崎病患儿的预后。

Objective To explore the incidence rate and risk factors of children Kawasaki disease(KD)complication with coronary artery lesion(CAL).Methods Totally 283 children with KD were retrospectively investigated,and they were divided into the CAL group and the NCAL group according to the occurrence of coronary artery disease.The incidence rate of CAL in children with KD was described,and the high risk factors of CAL in children with KD were screened byχ^2 test and multiple factors logistic regression methods.Results The incidence rate of CAL in 283 children with KD was 31.10%.The risk factors of CAL in children with KD included heating time(OR=2.818),delayed diagnosis and treatment(OR=3.459),hs-CRP(OR=3.815),erythrocyte sedimentation rate(OR=4.031),cTnI(OR=5.618)and IVIG resistance(OR=4.618).Conclusion Children KD have a high incidence rate of CAL.To aim directly at these above high risk factors,we should early screen,diagnose and treat children with KD,to cut down the incidence rate of CAL,and improve the prognosis of children with KD.