摘要
目的建立微波消解-电感耦合等离子体质谱(ICP-MS)测定衢枳壳中26种无机元素(Mg、K、Ca、Na、Al、V、Cr、Mn、Fe、Co、Ni、Cu、Zn、Ga、As、Se、Rb、Sr、Ag、Cd、Cs、Ba、Tl、Pb、U、Hg)的方法。方法样品经微波消解后,采用ICP-MS测定26种无机元素,并进行方法学验证。结果检测的26种元素线性关系良好(r≥0.9990),平均回收率为90%~111%,RSD均<5%,精密度、重复性和稳定性试验的RSD均符合定量分析要求,检出限为0.0007~7.2264μg·L^-1,测定的6批样品中Mg、K、Ca、Na、Al、Mn、Fe、Cu、Zn、Rb、Sr、Ba含量较高,V、Cr、Co、Ni、Ga、As、Cd、Cs、Tl、Pb、Hg、Se、Ag、U含量较低或未检出。结论该方法准确、快速、灵敏,适用于衢枳壳中多种无机元素的同时测定。
OBJECTIVE To establish an ICP-MS method for the determination of the amounts of inorganic elements(Mg,K,Ca,Na,Al,V,Cr,Mn,Fe,Co,Ni,Cu,Zn,Ga,As,Se,Rb,Sr,Ag,Cd,Cs,Ba,Tl,Pb,U,Hg)in Qu Aurantii Fructus.METHODS After the microwave digestion,26 kinds of inorganic elements in the samples were determined by ICP-MS,and the methodology was investigated.RESULTS The 26 kinds of inorganic elements showed the good linearity in the selected concentration ranges(r≥0.9990),with the average recovery were 90%-111%,while their RSDs were<5%.The RSD of the precision,repeatability and stability all met the demands of quantitative analysis.The detection limits were in the range o f 0.0007-7.2264μg·L^-1.The contents of Mg,K,Ca,Na,Al,Mn,Fe,Cu,Zn,Rb,Sr,Ba were higher in the six batchs of samples,and V,Cr,Co,Ni,Ga,As,Cd,Cs,Tl,Pb,Hg,Se,Ag,U were lower or not detected.CONCLUSION This method is accurate,rapid and sensitive,and can satisfy the simultaneous determination of elements in Qu Aurantii Fructus.
作者
郑明
金情政
王也
宋剑锋
胡卫南
徐礼萍
ZHENG Ming;JIN Qingzheng;WANG Ye;SONG Jianfeng;HU Weinan;XU Liping(Quzhou Institute for Food and Drug Control,Quzhou 324000,China;Zhejiang Quhua Hospital,Quzhou 324004,China)
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2020年第12期1493-1497,共5页
Chinese Journal of Modern Applied Pharmacy
基金
国家药品监督管理局中成药质量评价重点实验室(GZYZZ2020001)
衢州市科技计划指导性项目(2018024)。