小剂量阿司匹林联合硫酸镁与硝苯地平治疗妊娠高血压的临床疗效及对相关实验室指标、母婴结局的影响

Clinical efficacy of low-dose aspirin combined with magnesium sulfate and nifedipine in the treatment of pregnancy-induced hypertension and impacts on related laboratory indexes and maternal-infant outcomes

目的探讨小剂量阿司匹林联合硫酸镁与硝苯地平治疗妊娠高血压的临床效果及对相关实验室指标、母婴结局的影响。方法选取2016年3月~2019年3月我院收治的82例妊娠期高血压患者,随机分为A组与B组,每组41例。A组患者采用硫酸镁与硝苯地平进行治疗,B组联合采用小剂量阿司匹林、硫酸镁以及硝苯地平进行治疗,比较两组患者的临床疗效、相关实验室指标、不良反应以及母婴结局。结果B组患者的总有效率显著高于A组患者(P<0.05);B组不良反应总发生率及不良妊娠结局总发生率均低于A组(P<0.05);治疗后B组患者的血液黏稠度、红细胞积压、尿蛋白量各相关实验室指标明显改善,效果优于A组(P<0.05)。结论小剂量阿司匹林联合硫酸镁与硝苯地平可以有效控制妊娠期高血压,降低产后并发症不良发生率,改善相关实验室指标和母婴结局,保障患者与胎儿的安全,值得临床推广与运用。

Objective To investigate the clinical efficacy of low-dose aspirin combined with magnesium sulfate and nifedipine in the treatment of pregnancy-induced hypertension and impacts on related laboratory indexes and maternal-infant outcomes.Methods 82 patients with pregnancy-induced hypertension admitted to our hospital from March 2016 to March 2019 were randomly divided into group A(n=41)and group B(n=41).Patients in group A were treated with magnesium sulfate and nifedipine,while patients in group B were treated with low-dose aspirin combined with magnesium sulfate and nifedipine.The clinical efficacy,relevant laboratory indicators,adverse reactions and maternal-infant outcomes of the two groups were compared.Results The total efficacy rate of group B was significantly higher than that of group A(P<0.05).The total incidence of adverse reactions and adverse pregnancy outcomes in group B were lower than those in group A(P<0.05).After treatment,the blood viscosity,hematocrit and urine protein of group B were significantly improved,and the efficacy was better than that of group A(P<0.05).Conclusion Low-dose aspirin combined with magnesium sulfate and nifedipine can effectively control pregnancy-induced hypertension,reduce incidence of postpartum complications,improve relevant laboratory indicators and maternal-infant outcomes,and ensure the safety of patients and fetuses,which is worthy of clinical promotion and application.