丁苯酞序贯治疗对急性脑梗死预后的影响

Effect of sequential treatment with Butylphthalide on the prognosis of acute cerebral infarction

目的探讨丁苯酞序贯治疗对急性脑梗死预后的影响。方法选择2019年1~6月在我院诊断治疗的急性脑卒中患者100例为研究对象,随机分为观察组与对照组各50例。两组均给予常规治疗,观察组在此基础上给予丁苯酞序贯治疗。比较两组治疗前及治疗后NIHSS评分、MoCA评分、Barthel指数。结果(1)两组治疗后NIHSS评分较治疗前均显著下降,差异有统计学意义(P<0.05);治疗后观察组NIHSS评分显著低于对照组,差异有统计学意义(P<0.05)。(2)两组治疗后MoCA评分较治疗前均显著提高,差异有统计学意义(P<0.05);治疗后观察组MoCA水平显著高于对照组,差异有统计学意义(P<0.05)。(3)治疗后两组Barthel指数较治疗前均显著提高,差异有统计学意义(P<0.05);治疗后观察组Barthel指数高于对照组,差异有统计学意义(P<0.05)。结论丁苯酞序贯疗法急性脑梗死能提高预后、提高神经功能、改善患者的认知功能、改善患者的日常生活活动能力。

Objective To investigate the effect of sequential treatment with butylphthalide on the prognosis of acute cerebral infarction.Methods 100 patients with acute cerebral stroke who were diagnosed and treated in our hospital from January to June 2019 were selected as the study subjects,and they were randomly divided into observation group and control group,with 50 cases in each group.Both groups were given conventional treatment.The observation group was given sequential treatment with butylphthalide on this basis.The NIHSS score,MoCA score and Barthel index were compared between the two groups before and after treatment.Results(1)The NIHSS score of the two groups was decreased significantly after treatment compared with that before treatment,and the difference was statistically significant(P<0.05);the NIHSS score in the observation group was significantly lower than that in the control group after treatment,and the difference was statistically significant(P<0.05).(2)The MoCA score in the two groups after treatment was significantly higher than that before treatment,and the difference was statistically significant(P<0.05);after treatment,the MoCA level in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).(3)After treatment,the Barthel index in the two groups was significantly higher than that before treatment,and the difference was significant(P<0.05);the Barthel index in the observation group was higher than that in the control group after treatment,and the difference was significant(P<0.05).Conclusion Sequential treatment with butylphthalide for the treatment of acute cerebral infarction can improve patients’prognosis,improve neurological function,enhance the cognitive function,and improve the ability of daily life activities.