血清叶酸水平降低对血糖和脑梗死TOAST分型影响的研究

The influence of decreased serum folic acid levels on blood sugar and toast classification of cerebral infarction

目的揭示叶酸水平降低对血糖和脑梗死TOAST分型影响。方法选择叶酸水平降低合并脑梗死的患者191例,叶酸水平正常合并脑梗死的患者186例。比较两组患者实验室检查、脑梗死分型的不同特征、病灶分布、血管狭窄的特点。结果与叶酸正常脑梗死组相比,叶酸降低脑梗死组空腹血糖水平和糖化血红蛋白水平低,差异有统计学意义(P<0.05)。在两组患者的TOAST分型的心源性栓塞、大动脉粥样硬化和小动脉闭塞亚型对比中,头颈部血管狭窄或闭塞数目对比中,颅内动脉和颅外动脉各节段狭窄或闭塞的比例对比中,差异均无统计学意义(P>0.05)。叶酸正常脑梗死组是发生2型糖尿病的独立预测因子。结论血清叶酸水平降低的脑梗死患者体内有着较好的糖代谢状况。叶酸水平降低对脑梗死的TOAST分型、颅内颅外血管狭窄的分布无影响。

Objective The aim of this study is to reveal laboratory and imaging features of cerebral infarction patients with reduced folate levels.Methods There were 191 patients with reduced folate levels and cerebral infarction,and 186 patients with normal folate levels and cerebral infarction.The characteristics of laboratory examination,TOSAT classification of cerebral infarction,distribution of lesions and vascular stenosis were compared between the two groups.Results Compared with the cerebral infarction group with normal folic acid,the fasting blood glucose levels and glycated hemoglobin levels were lower in the cerebral infarction group with reduced folic acid(P<0.05).There was no significant difference in the TOAST classification between the two groups(P>0.05).There was no significant difference in the number of head and neck stenosis or occlusion between the two groups(P>0.05).There was no statistically significant difference in the proportion of intracranial artery and extracranial artery stenosis or occlusion between the two groups(P>0.05).The normal folate cerebral infarction group is an independent predictor of type 2 diabetes.Conclusion Cerebral infarction patients with lower serum folic acid levels have better glucose metabolism.Decreased folic acid levels had no effect on the TOAST classification of cerebral infarction and the distribution of intracranial and extracranial stenosis.