摘要
肌少症是骨骼肌质量和力量逐渐下降的过程,是老年人面临的主要健康挑战。线粒体可通过改善生物合成、抗氧化防御、融合/分裂动力学以及线粒体自噬等,维持骨骼肌自身结构和功能的完整性,线粒体功能障碍是导致肌少症的重要因素之一。运动疗法可通过激活与调控线粒体生物合成和线粒体自噬,调节线粒体质量控制,延缓和防治肌少症发生和进展。
Sarcopenia is a process in which skeletal muscle mass and strength are gradually declining,resulting a main health challenge for the old adults.Mitochondria can maintain the integrity of structure and function of skeletal muscle by improving biosynthesis,antioxidant defense,fusion/fission dynamics and mitophagy.Mitochondrial dysfunction is a important factor leading to the complex etiology of sarcopenia.Exercise can regulate mitochondrial quality control pathways by activating mitochondrial biogenesis and mitophagy to maintain optimal mitochondrial function,thereby delaying and preventing the onset and progression of sarcopenia.
作者
王岑依
梁计陵
司誉豪
陈宁
WANG Cen-yi;LIANG Ji-ling;SI Yu-hao;CHEN Ning(Soochow University School of Sport,Suzhou,Jiangsu 215021,China;John G.Rangos Sr.School of Health Sciences,Duquesne University,Pittsburgh,PA15282,USA;Graduate School,Wuhan Sports University,Wuhan,Hubei 430079,China;Tianjiu Research and Development Center for Exercise Nutrition and Foods,Hubei Key Laboratory of Sport Training and Monitoring,College of Health Science,Wuhan Sports University,Wuhan,Hubei 430079,China)
出处
《中国康复理论与实践》
CSCD
北大核心
2020年第9期1066-1070,共5页
Chinese Journal of Rehabilitation Theory and Practice
基金
国家自然科学基金面上项目(No.31571228)
湖北省体育教育与健康促进学科群项目
湖北省高等学校优秀中青年科技创新团队项目(No.T201624)。
关键词
肌少症
线粒体质量控制
运动干预
线粒体自噬
综述
sarcopenia
mitochondrial quality control
exercise intervention
mitophagy
review
