负压封闭引流技术联合局部加氧治疗糖尿病足慢性创面的临床研究

Clinical study of negative pressure closed drainage technology combined with local oxygenation in the treatment of chronic wounds of diabetic foot

目的研究负压封闭引流技术联合局部加氧治疗糖尿病足慢性创面的临床效果。方法选取2017年6月~2018年8月于我院接受治疗的100例糖尿病足慢性创面患者作为研究对象,按照随机数字法则分为两组,每组50例,其中观察组采用负压封闭引流技术联合局部加氧治疗;对照组采用负压封闭引流技术治疗,然后对比两组治疗效果,治疗前后两组液氧分压、LDH和SDH活性、T淋巴细胞亚群。结果观察组组织液氧分压(112.34±2.45)mmHg明显高于对照组的(60.34±1.28)mmHg,差异有统计学意义(P<0.05)。治疗后观察组的总有效率为98.00%,明显高于对照组(74.00%),差异有统计学意义(P<0.05)。治疗后,观察组LDH(132.23±1.23)U/L低于对照组,SDH(2.94±0.12)U/L高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组CD3^+、CD4^+、CD8^+均高于对照组,CD4^+/CD8^+低于对照组,差异有统计学意义(P<0.05)。结论糖尿病足慢性创面以负压封闭引流技术联合局部加氧治疗,能够提高治疗有效性,值得研究和推广。

Objective To study the clinical effect of negative pressure closed drainage technology combined with local oxygenation on chronic wounds of diabetic foot.Methods 100 patients with diabetic foot chronic wounds who were treated in our hospital from June 2017 to August 2018 were selected as study subjects.They were divided into two groups according to the random number table method,with 50 cases in each group.The observation group was treated with negative pressure closed drainage technology combined with local oxygenation;the control group was treated with negative pressure closed drainage technology.The treatment effects of the two groups were compared;the partial pressure of oxygen,lactate dehydrogenase(LDH)and succinate dehydrogenase(SDH)activity,and T lymphocytes of the two fluids before and after treatment were compared.Results The partial pressure of oxygen[(112.34±2.45)mmHg]in the observation group was significantly higher than that in the control group[(60.34±1.28)mmHg],and the difference was statistically significant(P<0.05).The total effective rate of the observation group after treatment was 98.00%,which was significantly higher than that of the control group(74.00%),and the differencewas statistically significant(P<0.05).After treatment,the LDH[(132.23±1.23)U/L]of the observation group was lower than that of the control group,and the SDH[(2.94±0.12)U/L]was higher than that of the control group,and the differences were statistically significant(P<0.05).After treatment,the cluster of differentiation CD3^+,CD4^+,and CD8^+of the observation group were higher than those of the control group,and CD4^+/CD8^+was lower than that of the control group,and the differences were statistically significant(P<0.05).Conclusion Negative pressure closed drainage technology combined with local oxygenation for chronic wounds of diabetic foot can improve the effectiveness of treatment and is worthy of research and promotion.