中空纤维感染模型概述及其应用于抗菌及抗病毒药物开发的研究现状

Current situation of hollow fiber infection model and its application in the research of antibacterial and antiviral agents

中空纤维感染模型(hollow fiber infection model,HFIM)是一种新药开发和应用的重要工具,被广泛应用于抗菌及抗病毒药物的试验中。该模型可用于研究体外抗菌活性(pharmacodynamics, PD)与抗菌药物的药代动力学行为(pharmacokinetics, PK)之间的关系,模拟体内给药后的连续变化,呈现患者体内的抗菌药物浓度-时间曲线。应用HFIM得到的实验结果与细菌杀灭的临床终点和出现耐药性的时间进程密切相,能够为后续药物临床试验的设计提供支持。

Hollow fiber infection model(HFIM) is an important tool for the development and utilization of new drugs,which is widely used in the trials of antibacterials and antivirals. This model can be used to study the relationship between the in vitro antibacterial activity(pharmacodynamics, PD) and the pharmacokinetics(PK) of antibacterial agents. Furthermore, it can also be used to simulate the continuous changes of agents in vivo after administration and describe the concentration-time curve of antibacterials observed in patients. The experimental results obtained by HFIM are closely related to the clinical endpoint of bacterium killing and the time course of drug resistance, which can provide support for the design of follow-up drug clinical trials.