注射用血栓通对脑缺血损伤的药理研究现状

Research status of pharmacology research on Xueshuantong injection for cerebral ischemia

注射用血栓通具有活血化瘀、通脉活络的功效,临床上可用于治疗多种疾病,如缺血性脑血管疾病、冠心病、心绞痛、心肌梗塞等。其主要成分为三七总皂苷,主要包括人参皂苷Rg1、Rb1、Rd、Re及三七皂苷R1,现代药理研究表明,三七总皂苷具有改善脑循环,保护缺血再灌注后脑和神经损伤等作用。本文就注射用血栓通及其主要成分对脑缺血损伤的药理作用研究现状进行总结性综述,以期对血栓通临床前研究及临床用药提供一定的参考。

Xueshuantong injection has the effect of activating blood circulation to remove blood stasis and promoting venous circulation. It can be used clinically to treat various diseases such as ischemic cerebrovascular disease,coronary heart disease,angina pectoris and myocardial infarction. Its main component is Panax notoginseng saponins,which mainly include ginsenoside Rg1, Rb1, Rd, Re and notoginsenoside R1. Modern pharmacological studies have shown that Panax notoginseng saponins can improve brain circulation and protect brain and nerve damage after ischemia-reperfusion. This article summarizes the research status of the pharmacological effects of Xueshuantong injection and its main components on cerebral ischemic injury, in order to provide a certain reference for preclinical research and clinical medication of Xueshuantong.