安宫牛黄丸联合常规西医治疗对老年急性脑梗死神经功能和凝血功能的影响

Effect of Angongniuhuang Pill Combined with Conventional Western Medicine on Nerve Function and Coagulation Function in Patients with Acute Cerebral Infarction

目的研究探讨安宫牛黄丸联合常规西医治疗对急性脑梗死患者神经功能和凝血功能的影响。方法选取2018年9月—2019年9月医院收治的94例急性脑梗死患者开展研究,随机数字表法分为观察组、对照组,各47例。对照组给予急性脑梗死的常规治疗,观察组在此基础上联合安宫牛黄丸治疗。对两组神经功能评分、凝血功能指标、生活质量评分、不良反应发生率等进行统计对比。结果观察组总有效率91.49%(43/47),高于对照组74.47%(35/47),组间比较差异有统计学意义(P <0.05)。治疗后观察组神经功能缺损评分(NIHSS)显著低于对照组,两组间对比差异有统计学意义(P <0.05);治疗后观察组凝血功能指标包括血小板计数(PLT)、纤维蛋白原(FIB)、D-二聚体(D-D)水平均低于对照组,两组间对比差异有统计学意义(P <0.05)。治疗后观察组生活质量评分包括生理健康、心理健康、社会关系、周围环境评分均高于对照组,两组间差异对比差异有统计学意义(P <0.05)。观察组不良反应发生率17.02%(8/47),对照组10.64%(5/47),组间比较差异无统计学意义(P> 0.05)。结论安宫牛黄丸对急性脑梗死患者治疗效果良好,能够改善神经功能评分,影响凝血功能,改善生活质量评分,不良反应发生率低,治疗安全性好,值得临床推广应用,可为老年急性脑梗死的治疗提供新的选择方案。

Objective To study the effect of Angongniuhuang pill combined with conventional western medicine on nerve function and coagulation function in patients with acute cerebral infarction. Methods 94 patients with acute cerebral infarction admitted to our hospital from September 2018 to September 2019 were selected for the study. They were randomly divided into observation group and control group with 47 cases in each group. The control group was given routine treatment of acute cerebral infarction,and the observation group was treated with Angong Niuhuang Pill. The neurological function score,coagulation function index,quality of life score and adverse reaction rate of the two groups were compared statistically. Results the total effective rate of the observation group was 91. 49%( 43/47),which was higher than that of the control group 74. 47%( 35/47). After treatment,the NIHSS of the observation group was significantly lower than that of the control group,and the difference between the two groups was statistically significant( P < 0. 05);after treatment,the levels of platelet count( PLT),fibrinogen( FIB),D-Dimer( D-D) of the observation group were lower than that of the control group,and the difference between the two groups was statistically significant( P < 0. 05). After treatment,the scores of quality of life in the observation group,including physical health,mental health,social relations and surrounding environment,were higher than those in the control group,and the difference between the two groups was statistically significant( P < 0. 05). The incidence of adverse reactions was 17. 02%( 8/47) in the observation group and 10. 64%( 5/47) in the control group. Conclusion Angongniuhuang pill has a good therapeutic effect on patients with acute cerebral infarction. It can improve patients’ neurological function score,affect patients’ coagulation function,improve patients’ quality of life score,and has a low incidence of adverse reactions. It has a good therapeutic safety. It is worthy of clinical application and can provide a new option for the treatment of old patients with acute cerebral infarction.