β2微球蛋白联合同型半胱氨酸检测及中医脉象对早期糖尿病肾病的诊断价值

Diagnostic Value of Microglobulin Combined with Homocysteine Test and Pulse Condition in Early Diabetic Nephropathy

目的研究β2微球蛋白联合同型半胱氨酸检测及中医脉象在早期糖尿病肾病中的临床诊断效果。方法随机抽取医院2018年1月—2020年5月就诊的50例糖尿病肾病患者作为糖尿病肾病组,同期抽取50例单纯糖尿病患者作为单纯糖尿病组,同期抽取50例健康体检者作为本研究对照组。三组分别进行β2微球蛋白联合同型半胱氨酸检测,在静息状态下进行中医脉象观察,分析三组β2微球蛋白、同型半胱氨酸水平及阳性检出率。结果糖尿病肾病组β2微球蛋白、同型半胱氨酸水平最高,对照组水平最低,糖尿病肾病组与其他两组比较,差异有统计学意义(P <0.05)。对照组与单纯糖尿病组比较,差异无统计学意义(P> 0.05)。糖尿病肾病β2微球蛋白、同型半胱氨酸及中医脉象阳性检出率最高,对照组最低,糖尿病肾病组与其他两组比较,阳性检出率差异有统计学意义(P <0.05)。对照组与单纯糖尿病组比较,阳性检出率差异无统计学意义(P> 0.05)。结论β2微球蛋白与同型半胱氨酸是检验肾脏功能的重要指标,通过两项指标的检测能准确了解肾脏功能受损情况,对糖尿病肾病诊断具有重要意义。在检测基础上,通过观察中医脉象方式,还能有效提升诊断可信度,降低误诊、漏诊情况发生,提升诊断效果,对早期糖尿病肾病诊断具有较大临床应用价值。

Objective To study the clinical diagnosis effect of β2-microglobulin combined with homocysteine detection and pulse condition of traditional Chinese medicine in early diabetic nephropathy. Methods A total of 50 diabetic nephropathy patients from January 2018 to may 2020 in our hospital were randomly selected as diabetic nephropathy group,50 simple diabetic patients as simple diabetic group and 50 healthy persons as control group. The three groups were tested with β2-microglobulin and homocysteine respectively. The pulse condition of Chinese medicine was observed in resting state. The level and positive detection rate of β2-microglobulin and homocysteine were analyzed. Results The levels of β2-microglobulin and homocysteine were the highest in diabetic nephropathy group and the lowest in control group. The difference between diabetic nephropathy group and other two groups was statistically significant( P < 0. 05). There was no significant difference between the control group and the simple diabetes group( P > 0. 05). The positive rate of β2-microglobulin,homocysteine and pulse condition of traditional Chinese medicine was the highest in diabetic nephropathy,and the lowest in the control group. Compared with the other two groups,the positive rate of diabetic nephropathy was statistically significant( P < 0. 05). There was no significant difference between the control group and the simple diabetes group( P > 0. 05). Conclusion β2-microglobulin and homocysteine are important indexes for the detection of renal function. The detection of these two indexes can accurately understand the damage of renal function,which is of great significance for the diagnosis of diabetic nephropathy. On the basis of detection,by observing the pulse pattern of traditional Chinese medicine,it can effectively improve the reliability of diagnosis,reduce the occurrence of misdiagnosis and missed diagnosis,and improve the diagnosis effect,which has great clinical application value for the diagnosis of early diabetic nephropathy.