非蛋白尿型糖尿病肾病

Non⁃proteinuria diabetic nephropathy

糖尿病肾病是糖尿病最常见的严重并发症,也是慢性肾脏病进展到终末期肾脏病的主要病因之一。糖尿病肾病早期表现为肾小球内高压力、高灌注和高滤过,随后出现微量白蛋白尿、显性蛋白尿、肾小球滤过率降低,最终可发展为终末期肾病。近年来,糖尿病患者蛋白尿的发生率有所下降,但肾小球滤过率减低的发生率上升,提示非蛋白尿型糖尿病肾病的发病率升高,引起多种血管并发症和肾功能降退。因此,了解非蛋白尿型糖尿病肾病的发病机制,诊断标志物和治疗措施,是有效治疗糖尿病肾病改善疾病预后的基础。

As the major complication of diabetes,diabetic nephropathy is also the major cause of progression from chronic kidney disease to end stage renal disease.However,the incidence of non⁃proteinuria diabetic nephropathy(NP⁃DN)in patients with type 2 diabetes is gradually increasing,causing vascular complications and renal function decrease.Therefore,understanding the pathogenesis,diagnostic markers and therapies of NP⁃DN is the basis of effective treatment of diabetic nephropathy.