不同民族多囊卵巢综合征患者抗苗勒氏管激素水平的相关研究

Study on the level of anti-Müllerian hormone in patients with polycystic ovary syndrome of different nationalities

目的探讨新疆维吾尔自治区维吾尔族和汉族多囊卵巢综合征(PCOS)患者血清抗苗勒氏管激素(AMH)水平间的差异,分析AMH水平与体质量指数(BMI)、性激素和糖代谢相关指标间的关系。方法选取PCOS患者200例为研究对象,其中维吾尔族和汉族患者各100例,根据BMI是否大于25 kg/m2分为维吾尔族肥胖组(40例)和维吾尔族非肥胖组(60例)、汉族肥胖组(34例)和汉族非肥胖组(66例);另选取维吾尔族和汉族健康育龄期女性各50例分别作为维吾尔族对照组和汉族对照组。比较各组AMH、性激素[卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)和睾酮(T)]、糖代谢相关指标[空腹血糖、空腹胰岛素、稳态模型胰岛素抵抗指数(HOMA-IR)]水平;采用Pearson相关分析AMH水平与各指标间的相关性。结果维吾尔族肥胖组、维吾尔族非肥胖组AMH、T水平均高于维吾尔族对照组(P<0.05),FSH、LH、E2水平均低于维吾尔族对照组(P<0.05);维吾尔族肥胖组AMH、LH水平均低于维吾尔族非肥胖组(P<0.05),FSH、E2、T水平均高于维吾尔族非肥胖组(P<0.05)。汉族肥胖组、汉族非肥胖组AMH、T水平均高于汉族对照组(P<0.05),FSH、LH、E2水平均低于汉族对照组(P<0.05);汉族肥胖组AMH、LH水平均低于汉族非肥胖组(P<0.05),FSH、E2、T水平均高于汉族非肥胖组(P<0.05)。Pearson相关分析结果显示,AMH水平与BMI、FSH、E2、空腹血糖、空腹胰岛素和HOMA-IR水平均呈负相关(P<0.05),与LH、T水平均呈正相关(P<0.05)。结论AMH水平在汉族与维吾尔族PCOS患者中无明显差异,但相同民族肥胖与非肥胖PCOS患者AMH水平存在差异。

Objective To explore the difference between the serum anti-Müllerian hormone(AMH)levels of Uygur and Han polycystic ovary syndrome(PCOS)patients in Xinjiang Uygur Autonomous Region,and analyze the relationship between AMH levels and body mass index(BMI),sex hormones and glucose metabolism related indexes.Methods A total of 200 PCOS patients were selected as the research objects,including 100 Uygur and 100 Han patients,according to whether BMI was higher than 25 kg/m2,they were divided into Uygur obesity group(40 cases),Uygur non-obesity group(60 cases),Han obesity group(34 cases)and Han non-obesity group(66 cases).In addition,50 Uygur and 50 Han women of childbearing age were selected as Uygur control group and Han control group respectively.The levels of AMH,sex hormones[follicle stimulating hormone(FSH)),luteinizing hormone(LH),estradiol(E2)and testosterone(T)],glucose metabolism related indexes[fasting blood glucose,fasting insulin,homeostasis model insulin resistance index(HOMA-IR)]in each group were compared.Pearson correlation analysis was used to analyze the correlation between AMH level and each index.Results AMH and T levels in Uygur obesity group and Uygur non-obesity group were higher than those in Uygur control group(P<0.05),and FSH,LH,E2 levels were lower than those in Uygur control group(P<0.05).AMH and LH levels in Uygur obesity group were lower than those in Uygur non-obesity group(P<0.05),and FSH,E2 and T levels were higher than those in Uygur non-obesity group(P<0.05).AMH and T levels in Han obesity group and Han non-obesity group were higher than those in Han control group(P<0.05),and FSH,LH,E2 levels were lower than those in Han control group(P<0.05).AMH and LH levels in Han obesity group were lower than those in Han non-obesity group(P<0.05),and FSH,E2 and T levels were higher than those in Han non-obesity group(P<0.05).Pearson correlation analysis showed that AMH level negatively correlated with BMI,FSH,E2,fasting blood glucose,fasting insulin and HOMA-IR levels(P<0.05),and positively correlated with LH and T levels(P<0.05).Conclusion There is no significant difference on AMH levels between Han and Uygur PCOS patients,but there are differences on AMH levels between obesity PCOS and non-obesity patients in the same nationality.