炎症因子水平与老年缺血性脑血管病患者介入治疗预后的关系研究

Relationship between inflammatory factors levels and prognosis of elderly patients with ischemic cerebrovascular disease after interventional therapy

目的探讨核因子(NF)-κB、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、血管细胞黏附因子-1(VCAM-1)及超敏C反应蛋白(hs-CRP)水平与老年缺血性脑血管病患者介入治疗预后的关系。方法选取2018年1月至2019年9月唐山市人民医院神经内科收治的老年缺血性脑血管病患者86例为观察组,同期健康体检者59例为对照组。采用酶联免疫吸附试验检测两组NF-κB、IL-1、IL-6、IL-8、VCAM-1水平;采用免疫比浊法检测两组hs-CRP水平。比较两组NF-κB、IL-1、IL-6、IL-8、hs-CRP、VCAM-1水平;分析NF-κB、IL-1、IL-6、IL-8、hs-CRP、VCAM-1水平与老年缺血性脑血管病患者介入治疗预后的相关性。结果观察组治疗前hs-CRP、NF-κB、IL-1、IL-6、IL-8及VCAM-1水平均高于对照组,差异有统计学意义(P<0.05)。治疗后预后良好患者hs-CRP、NF-κB、IL-1、IL-6、IL-8及VCAM-1水平均低于预后不良患者,差异有统计学意义(P<0.05)。相关性分析结果显示,老年缺血性脑血管病患者介入治疗预后与hs-CRP、NF-κB、IL-1、IL-6、IL-8及VCAM-1水平均呈负相关(P<0.05)。结论hs-CRP、NF-κB、IL-1、IL-6、IL-8及VCAM-1在老年缺血性脑血管病患者中呈高表达,且与患者介入治疗预后相关,可用于患者的预后评估。

Objective To investigate the relationship between the levels of nuclear factor(NF)-κB,interleukin-1(IL-1),interleukin-6(IL-6),interleukin-8(IL-8),vascular cell adhesion factor-1(VCAM-1),high-sensitivity C-reactive protein(hs-CRP)and prognosis of elderly patients with ischemic cerebrovascular disease after interventional therapy.Methods A total of 86 elderly patients with ischemic cerebrovascular disease admitted to the Department of Neurology,Tangshan People′s Hospital from January 2018 to September 2019 were selected as the observation group,and 59 healthy people during the same period were selected as the control group.Enzyme linked immunosorbent assay was used to detect the levels of NF-κB,IL-1,IL-6,IL-8 and VCAM-1,and the levels of hs-CRP were detected by immunoturbidimetry.The levels of NF-κB,IL-1,IL-6,IL-8,hs-CRP and VCAM-1 were compared between the two groups.The correlations between the levels of NF-κB,IL-1,IL-6,IL-8,hs-CRP,VCAM-1 and prognosis of elderly patients with ischemic cerebrovascular disease after interventional therapy were analyzed.Results The levels of hs-CRP,NF-κB,IL-1,IL-6,IL-8 and VCAM-1 in the observation group before treatment were higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of hs-CRP,NF-κB,IL-1,IL-6,IL-8 and VCAM-1 in patients with good prognosis were lower than those in patients with poor prognosis,the differences were statistically significant(P<0.05).Correlation analysis showed that the prognosis of interventional therapy in elderly patients with ischemic cerebrovascular disease negatively correlated with the levels of hs-CRP,NF-κB,IL-1,IL-6,IL-8 and VCAM-1(P<0.05).Conclusion hs-CRP,NF-κB,IL-1,IL-6,IL-8 and VCAM-1 highly express in elderly patients with ischemic cerebrovascular disease,and relate to the prognosis of patients with interventional therapy,and could be used for prognostic evaluation.