摘要
目的：商陆皂苷甲（ＥｓＡ）对大鼠Ｈｅｙｍａｎｎ肾炎（ｐａｓｉｖｅＨｅｙｍａｎｎｎｅｐｈｒｉｔｉｓ，ＰＨＮ）的治疗作用及机理。方法：大鼠ｓｃＦｘ１Ａ抗原的抗体制成自身免疫性肾小球肾炎，ＥｓＡ５，１０和２０ｍｇ·ｋｇ－１·ｄ－１ｉｐ，连续１４ｄ。结果：ＥｓＡ可以显著减少肾炎大鼠尿蛋白的产生，电镜和免疫荧光检查发现ＥｓＡ治疗后肾炎大鼠病理情况明显好转。ＥｓＡ治疗对血清中炎性细胞因子肿瘤坏死因子（ＴＮＦ）、白细胞介素１（ＩＬ１）和白细胞介素６（ＩＬ６）的产生具有显著的抑制作用。结论：ＥｓＡ对大鼠Ｈｅｙｍａｎｎ肾炎具有显著治疗作用。
AIM: To investigate the therapeutic effects of esculentoside A, a kind of saponin isolated from the root of the Chinese herb Phytolaca esculenta , on passive Heymann nephritis (PHN) in rats. METHODS: PHN was prepared by injecting Fx1A antibody in rats, and esculentoside A 5, 10 and 20 mg·kg -1 were administered intraperitonealy once a day for 14 consecutive days for the treatment of PHN rats. RESULTS: Esculentoside A 5, 10 and 20 mg·kg -1 decreased urine protein production significantly. Pathological analysis revealed that deposits of IgG along the capillary wall of the glomerulus, glomerulus base membrane thickness and electron dense deposits in PHN rats after treatment with esculentoside A were less than those in control rats. Decreased levels of TNF, IL 1 and IL 6 were observed in the sera of PHN rats following esculentoside A administration. TNF, IL 1 and IL 6 are important cytokines involved in the pathogenesis of inflammatory lesions. CONCLUSION: Esculentoside A possessed potent anti inflammatory effects on PHN. Inhibition of inflammatory cytokine production may partially explain the anti inflammatory effects of esculentoside A.
出处
《药学学报》
CAS
CSCD
北大核心
1999年第1期9-12,共4页
Acta Pharmaceutica Sinica
基金
国家自然科学基金
