药物涂层球囊治疗下肢动脉疾病研究进展

Research progress of drug-coated balloon therapy for lower extremity atherosclerotic disease

下肢动脉疾病(LEAD)是由动脉粥样硬化引起的下肢动脉管腔狭窄、闭塞,导致相应肢体出现缺血症状的一类疾病。腔内介入是治疗LEAD的主要方式,包括经皮腔内血管成型术(PTA)及支架植入术,但术后再狭窄率较高。药物涂层球囊(DCB)可在抑制血管内膜增生及炎症反应的同时避免腔内异物存留,对于原发病变及支架内再狭窄均有较好疗效。本文对DCB作用原理及其治疗LEAD应用现状和研究进展进行综述。

Lower extremity artery disease(LEAD)is a kind of disease caused by atherosclerosis,which leads to narrowing and occlusion of lower extremity artery and causes ischemia symptoms of corresponding limbs.Endovascular intervention has become the main treatment method for LEAD,mainly including percutaneous transluminal angioplasty(PTA)and stent implantation,but high restenosis rate is still unavoidable after treatment.Drug-coated balloon(DCB)can inhibit intimal hyperplasia and inflammation while avoid the retention of foreign bodies,having good therapeutic effects on both primary lesions and in-stent restenosis.The principle of DCB therapy,application status and research advancements of DCB for LEAD were reviewed in this article.