依达拉奉联合硫酸氢氯吡格雷治疗急性脑梗死对患者神经功能的影响研究

Effect of edaravone combined with clopidogrel bisulfate on neurological function in patients with acute cerebral infarction

目的探讨依达拉奉联合硫酸氢氯吡格雷治疗急性脑梗死对患者神经功能的影响。方法选取本院2018年9月至2019年12月收治的急性脑梗死患者60例。根据入院时间顺序随机分为对照组(n=30)和研究组(n=30)。对照组患者采取单药硫酸氢氯吡格雷片进行治疗,研究组患者则在对照组的基础上联合依达拉奉注射液进行治疗。观察并比较两组患者神经功能缺损情况、治疗效果及不良反应的发生情况。结果治疗后,研究组美国国立卫生研究院神经功能缺损量表(NIHSS)评分低于对照组,差异有统计学意义(P<0.05)。研究组患者治疗总有效率明显高于对照组,差异有统计学意义(P<0.05)。研究组不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论依达拉奉联合硫酸氢氯吡格雷治疗急性脑梗死,效果显著,对患者神经功能缺损改善也有积极作用,且安全性较高。

Objective To investigate the effect of edaravone combined with clopidogrel bisulfate on neurological function in patients with acute cerebral infarction.Methods 60 patients with acute cerebral infarction admitted to our hospital from September 2018 to December 2019 were selected.They were randomly divided into control group(n=30)and study group(n=30)according to the time sequence of admission.The patients in the control group were treated with clopidogrel bisulfate tablets.The patients in the study group were treated with edaravone injection on the basis of the control group.The neurological deficits,therapeutic effects and adverse reactions of the two groups were observed and compared.Results The NIHSS score in the study group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).The total clinical effective rate of the study group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of edaravone and clopidogrel bisulfate is effective in the treatment of acute cerebral infarction,and has a positive effect on the improvement of neurological deficits in patients with high safety.