手术后吉西他滨和表柔比星序贯膀胱灌注治疗非肌层浸润性膀胱癌患者的效果

Effect of sequential intravesical instillation of gemcitabine and epirubicin on patients with Nonmuscular invasive bladder cancer after operation

目的分析手术后吉西他滨、表柔比星序贯膀胱灌注治疗非肌层浸润性膀胱癌患者的效果。方法选取本院2017年2月至2018年6月收治的非肌层浸润性膀胱癌患者88例,按照随机数表法分为研究组和对照组,每组44例。对照组给予表柔比星序贯膀胱灌注治疗,研究组在对照组的基础上加用吉西他滨,两组均治疗1年。比较两组患者膀胱癌复发率、不良反应发生率及导管留置时间和住院时间。结果研究组导管留置时间和住院时间均短于对照组(P<0.05),且研究组患者尿路刺激、骨髓抑制、血尿、胃肠道反应等不良反应发生率明显低于对照组(P<0.05)。研究组患者膀胱癌复发率显著低于对照组(P<0.05)。结论手术后吉西他滨、表柔比星序贯膀胱灌注治疗非肌层浸润性膀胱癌患者的效果确切,能缩短患者住院时间,减轻患者经济负担,有效避免患者产生肝肾功能受损、发热、尿道狭窄等不良反应,安全性高,预后良好,可在非肌层浸润性膀胱癌的临床治疗中推广使用。

Objective To analyze the effect of sequential intravesical instillation of gemcitabine and epirubicin in the treatment of non-muscular invasive bladder cancer.Methods 88 patients with non-muscular invasive bladder cancer admitted to our hospital from February 2017 to June 2018 were selected and divided into study group and control group according to random number table method,with 44 cases in each group.The control group was treated with epirubicin sequential bladder instillation,while the study group was treated with gemcitabine on the basis of the control group.Both groups were treated for one year.The recurrence rate of bladder cancer,incidence of adverse reactions,indwelling time of catheter and hospitalization time were compared between the two groups.Results The catheter indwelling time and hospitalization time in the study group were shorter than those in the control group(P<0.05),and the incidence of adverse reactions such as urinary tract stimulation,bone marrow suppression,hematuria and gastrointestinal reactions in the study group was significantly lower than those in the control group(P<0.05).In terms of recurrence rate,the recurrence rate of bladder cancer in the study group was significantly lower than that in the control group(P<0.05).Conclusion Sequential bladder instillation of gemcitabine and epirubicin after operation is effective in the treatment of patients with non-muscular invasive bladder cancer.It can shorten the hospitalization time of patients,reduce the economic burden of patients,effectively avoid adverse reactions such as liver and kidney function damage,fever,urethral stricture and so on.It has high safety and good prognosis.It can be used in non-muscular layer.Promotion of clinical treatment of invasive bladder cancer.