腹腔微环境与胃癌腹膜转移关系的研究进展

Research progress of relationship between peritoneal micro-environment and peritoneal metastasis of gastric cancer

腹膜转移是晚期胃癌的主要转移方式之一,关于胃癌腹膜转移的发生机制尚不明确。“种子土壤”学说是较被认可的腹膜转移理论。腹腔内多种细胞成分、细胞外基质以及腹腔积液共同构成腹腔微环境,可为胃癌细胞种植、浸润、生长以及转移提供适宜的生存条件。充分认识腹腔微环境,有利于早期判别胃癌腹膜转移的发生与肿瘤复发,并能够为未来寻找靶向腹腔微环境的药物提供理论依据。笔者查阅国内外相关文献,就参与构成腹腔微环境的主要细胞成分、腹腔积液以及免疫微环境进行综述,探讨腹腔微环境与胃癌腹膜转移的关系。

Peritoneal metastasis is one of the most frequent metastatic patterns of advanced gastric cancer,but the mechanism underlying remains unclear.The‘seed and soil’theory is now well recognized for peritoneal metastasis of gastric cancer at present.The combination of various cells,extracellular matrix,and ascites components within the abdominal cavity provide a suitable microenvironment for the plantation,infiltra-tion,growth and metastasis of gastric cancer cells.Fully under-standing of peritoneal microenvironment will help to diagnose the peritoneal metastasis of gastric cancer and tumor recurrence,and provide theoretical basis for the development of drugs targeting peritoneal microenvironment.The authors review the main cell formation,ascites and immune microenvironment involved in the formation of the peritoneal microenvironment based on relevant literatures at home and abroad,and investigate the relationship between peritoneal microenvironment and peritoneal metastasisof gastric cancer.