桑翘解热汤联合磷酸奥司他韦治疗甲型.H1N1流感(风热犯卫型)临床观察

Clinical Observation of Using Sangqiao Jiere Decoction Combined with Oseltamivir Phosphate in the Treatment of Influenza A(H1N1)

目的:探索桑翘解热汤联合磷酸奥斯他韦对甲型H1N1流感(风热犯卫型)的临床疗效。方法:将118例甲型H1N1流感患者随机分为观察组与对照组,观察组60例予桑翘解热汤联合磷酸奥斯他韦75mg,每天2次,对照组58例予磷酸奥斯他韦75mg,每天2次,在治疗第3、5d时对比两组患者的退热率和咽拭子流感病毒转阴率,治疗第5d后对比IFN-γ/IL-4比值,并对比两组患者肺炎的发病率。结果:观察组3d退热率(P=0.044<0.05)和5d退热率均优于对照组(P=0.038<0.05),治疗5d后观察组以95.0%的流感病毒转阴率优于对照组的82.7%(P<0.05),肺炎发生率无统计学差异(Fisher值=0.268),观察组IFN-γ/IL-4比值的改善经治疗后,优于对照组(P=0.006<0.01)。结论:桑翘解热汤联合磷酸奥斯他韦治疗甲型H1N1流感(风热犯卫型)退热快,咽拭子检测流感病毒转阴率高,缩短患者病程,提高临床疗效。

Objective: To explore the clinical efficacy of Sangqiao Jiere Decoction combined with Oseltamivir Phosphate in the treatment of influenza A( H1 N1). Methods: 118 patients with influenza A( H1 N1) were randomly divided into observation group and controlled group. 60 patients in the observation group were treated with Sangqiao Jiere Decoction combined with 75 mg,bid of Oseltamivir Phosphate. 58 patients in the controlled group were treated with 75 mg,bid of Oseltamivir Phosphate. The fever abatement rate and negative conversion rate of swab influenza virus were compared between the two groups on the 3 rdand 5 th day of treatment. The ratio of IFN-gamma/IL-4 was compared,and the incidence of pneumonia was compared between the two groups. Results: The antipyretic rate of 3 days( P = 0. 044<0. 05) and 5 days in the observation group was better than that in the controlled group( P = 0. 038<0. 05). After 5 days of treatment,the negative rate of influenza virus in the observation group was higher than that in the controlled group( 82. 7%,P<0. 05),and the incidence of pneumonia had no statistical difference( Fisher value = 0. 268). The improvement of IFN-gamma/IL-4 ratio in the observation group was better than that in the controlled group( P<0. 05). After treatment,it was better than the controlled group( P = 0. 006<0. 01). Conclusion: Sangqiao Jiere Decoction combined with Oseltamivir Phosphate can reduce fever quickly in the treatment of influenza A( H1 N1) influenza,and the negative rate of influenza virus detected by pharyngeal swab is high,which can shorten the course of disease and improve the clinical efficacy.