2型糖尿病及非糖尿病患者的RDW与ACS冠状动脉病变严重程度的相关性分析

The correlation between RDW of type 2 diabetes mellitus or non-diabeticpatients and severity of acute coronary syndrom

目的探讨急性冠状动脉综合征(acute coronary syndrome,ACS)冠状动脉血管严重程度与2型糖尿病(type 2 diabetes mellitus,2-DM)及非糖尿病患者红细胞分布宽度(red cell volume distribution width,RDW)水平的相关性。方法选择ACS患者497,分为2-DM组(1组)213例、血糖正常组(2组)284例,分别行冠状动脉造影(coronary arteriography,CAG)根据SYNTAX评分将1组及2组分别为低分组(A组)、中分组(B组)、高分组(C组),测定各组的RDW,进行比较及相关性分析;测定1组内A、B、C 3组间的糖化血红蛋白水平,进行组内比较及相关性分析。结果1组中A1、B1、C1与2组中A2、B2、C2 RDW水平进行性升高,差异有统计学意义(P<0.05),且RDW水平与SYNTAX评分呈正相关(r=0.675,P<0.01)。所有入选497例患者的RDW水平与SYNTAX评分呈正相关(r=0.686,P=0.041)。1组与2组RDW水平与SYNTAX评分相关系数差异无统计学意义(Z=-1.960,P=0.373)。结论RDW不受血糖水平影响,不论是2-DM患者还是血糖正常的患者,均可以作为ACS冠状动脉血管严重程度的评价指标。

Objective To investigate the correlation between the severity of acute coronary syndrome(ACS)and red blood cell distribution width(RDW)of type 2 diabetes mellitus(DM)and non-diabetic patients.Methods The 497 ACS patients were selected and divided into the 2-DM group(group 1)and the non-diabetic group(group 2),performed coronary angiography(CAG)separately.According to SYNTAX score,group 1 and group 2 were divided into three groups:low group,middle group and high group(group 1:A1,B1,C1;group 2:A2,B2,C2),measuring the RDW width of each group,and conducting comparison and correlation analysis.Glycated hemoglobin(GHb)levels between groups A1,B1 and C1 were measured,and intra-group comparison and correlation analysis were performed.Results The RDW level of A1,B1,C1 in group 1 and A2,B2 and C2 in group 2 was progressively increased with statistically significant difference(P<0.05),and the RDW level was positively correlated with SYNTAX score(r=0.675,P<0.01).The RDW level of all 497 patients was positively correlated with SYNTAX score(r=0.686,P=0.041).There was no statistically significant difference in the correlation coefficient between RDW level and SYNTAX score(Z=-1.960,P=0.373)between groups 1 and 2.Conclusion The width of the red blood cells was not affected by the blood glucose level.Whatever type 2 diabetes mellitus and non-diabetic patients,RDW can be used as the evaluation index of the severity of ACS coronary blood vessels.