RNA hs_circ_0021001在颅内动脉瘤患者治疗及预后评估中的应用

Application of RNA hsa_circ_0021001 in the Treatment and Progno-sis Evaluation of Patients with Intracranial Aneurysms

目的探讨RNA hs_circ_0021001在颅内动脉瘤患者治疗及预后评估中的价值。方法选取2008年1月至2015年1月乐山市人民医院收治的156例颅内动脉瘤患者为研究对象。选取同期体检健康者80例作为对照组。比较两组受试者hs_circ_0021001相对表达量。采用单因素及多因素Logistic回归分析影响患者预后不良的相关因素。采用受试者工作特征曲线(ROC)分析hs_circ_0021001诊断患者预后不良的效能。结果颅内动脉瘤组患者hs_cire_0021001相对表达量为(3.52±0.74),明显低于对照组的[(11.31±1.53),P<0.05]。治疗后颅内动脉瘤患者hs_circ_0021001相对表达量为(5.18±1.32),明显高于治疗前(P<0.05)。单因素及多因素Logistic回归分析显示动脉瘤大小、动脉瘤位置、Hunt-Hess分级及hs_circ_0021001与患者预后不良密切相关。h_circ_0021001评估颅内动脉瘤患者预后不良AUC、敏感度、特异性分别为0.780(0.707~0.843)、71.74%、89.09%。结论hs_circ_0021001与颅内动脉瘤患者预后密切相关,可辅助诊断颅内动脉瘤患者预后。

Objective To explore the application of RNA hs_circ_0021001 in the treatment and prognosis evaluation of patients with intracranial aneurysms.Methods One hundred and ftysix patients with intracranial aneurysms admitted to Leshan People’s Hospital from January 2008 to January 2015 were selected as the study subjects.Eighty healthy persons in the same period were selected as control group.The relative expression of hs_circ_0021001 was compared between the two groups.Univariate and multivariate logistic regression analysis was used to analyze the factors related with the poor prognosis of patients.Subject operating characteristic curve(ROC)was used to analyze the effectiveness of hs_circ_0021001 in predicting poor prognosis.Results The relative expression of hs_circ_0021001 in the intracranial aneurysm group was(3.52±0.74),which was significantly lower than that in the control group[(11.31±1.53),P<0.05].The relative expression of hs_circ_0021001 in patients with intracranial aneurysms after treatment was(5.18±1.32),which was significantly higher than that before treatment(P<0.05).Univariate and multi variate Logistic analysis showed that aneurysm size,aneurysm location,Hunt-Hess grade and hs_circ_0021001 were closely related to poor prognosis.The AUC,sensitivity and specificity of hs_circ_0021001 in evaluating poor prognosis of patients with intracranial aneurysms were 0.780(0.707-0.843),71.74%and 89.09%,respectively.Conclusion hs_circ_0021001 is closely related to the survival and prognosis of patients with intracranial aneurysms,and can be used to predict the prognosis of patients with intracranial aneurysms.