摘要
目的总结目前结直肠癌患者血清外泌体microRNAs的相关研究进展。方法通过文献检索,收集和整理近年来关于结直肠癌患者血清外泌体microRNAs相关的国内外文献进行阅读并作综述。结果外泌体是一种外囊泡,其中包含脂质、蛋白质、DNA、RNA(mRNA、microRNA和长链非编码RNA)和其他分子。这种囊泡通过转运上述分子从而介导了细胞间的通讯。血清中的外泌体是血循环系统中microRNAs的主要载体。血清外泌体microRNAs可影响结直肠癌细胞的增殖、侵袭和转移,介导结直肠癌细胞耐药,并且可作为一种生物标志物预测结直肠癌的预后。结论血清外泌体microRNAs在调控结直肠癌的发生发展、治疗、诊断等方面均具有重要作用,其作为一种生物标志物,在结直肠癌的早期诊断、预后评估等方面具有巨大的潜力。
Objective To summarize the current research progress of serum exosome microRNAs in patients with colorectal cancer.Methods The domestic and foreign literatures related to serum exosome microRNAs of colorectal cancer patients,which had been reported in recent years were collected through literature search.Subsequently,those literatures were used to read and review.Results Exosomes were extracellular vesicles,which contained lipids,proteins,DNA,RNA(mRNA,microRNA,and long non-coding RNA),and other molecules.These vesicles mediated communication between cells by transporting the above molecules.Exosomes in serum were the main carriers of microRNAs in the blood circulation system.Serum exosome microRNAs could affect the proliferation,invasion,and metastasis of colorectal cancer cells,mediate the drug resistance of colorectal cancer cells,and could be used as biomarkers to predict the prognosis of colorectal cancer.Conclusions Serum exosome microRNAs play important role in the occurrence,development,treatment,and diagnosis of colorectal cancer.As a class of biomarker,serum exosome microRNAs have great potential in the early diagnosis and prognostic evaluation of colorectal cancer.
作者
薛源
李沛东
张广军
XUE Yuan;LI Peidong;ZHANG Guangjun(The Second Department of Gastrointestinal Surgery,The Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan 637000,P.R.China;Institute of Hepatobiliary,Pancreatic,and Intestinal Disease,North Sichuan Medical College,Nanchong,Sichuan 637000,P.R.China)
出处
《中国普外基础与临床杂志》
CAS
2020年第9期1169-1174,共6页
Chinese Journal of Bases and Clinics In General Surgery
基金
四川科技厅青年基金(项目编号:2017JQ0039)
南充市市校科技战略合作专项(项目编号:18SXHZ0577)
四川省卫生健康委员会重点项目(项目编号:19ZD005)
川北医学院附属医院重点项目(项目编号:2019ZD004)。