长链非编码RNA-MALAT1在胃癌中的研究进展

Research Progress of Long Non-coding RNA-MALAT1 in Gastric Cancer

胃癌(gastric cancer,GC)是我国常见癌症之一,目前其发生发展机制尚不明确。长链非编码RNA(long non-coding RNA,lnc-RNA)在人类基因调控中起重要作用,其中肺腺癌转移相关转录子1(metastasis-associated lung adenocarcinoma transcript 1,MALAT1)与多种疾病的发生、发展有关,在各种癌症中表达均上调。MALAT1在人胃癌组织中的表达较癌旁组织显著上升。实验证明,MALAT1可通过多种通路调控人体基因表达,或通过促进上皮间充质转化(epithelial-mesenchymal transition,EMT)促进胃癌的发生、发展及侵袭、转移。全文就MALAT1在胃癌中作用的研究进展进行综述。

Gastric cancer(GC) is one of the most common cancers in China. Long non-coding RNA(lnc-RNA) plays an important role in human gene regulation,among which metastasis-associated lung adenocarcinoma transcript 1(MALAT1) is related to occurrence and development of many diseases,and is up-regulated in various cancers. Compared with paracancerous tissues,MALAT1 expression is increased significantly in human gastric cancer tissues. Studies show that MALAT1 can promote occurrence,development,invasion and metastasis of GC by regulating human gene expression through various pathways,or by promoting epithelial-mesenchymal transition(EMT).The role of MALAT1 in gastric cancer is reviewed in this article.