不同消化道肿瘤新辅助治疗后手术间隔时间的研究进展

Progress on the Interval between Neoadjuvant Therapy and Surgical Treatment for Different Digestive Tract Tumors

消化道肿瘤的发病率及死亡率在所有肿瘤中位居前列。新辅助治疗对于提高进展期肿瘤患者的手术机会和R0切除率至关重要,寻找新辅助治疗后的最佳手术介入时机,能够为患者带来最大的手术获益。全文对既往不同消化道肿瘤新辅助治疗后手术间隔时间的相关研究进行回顾,分析不同手术间隔时间对于围手术期并发症、术后病理缓解率及远期生存率的影响,并总结目前新辅助治疗和手术间隔时间存在的一些问题及发展前景。

The morbidity and mortality of the digestive tract tumors take the lead in all tumors.Neoadjuvant therapy is important to improve the surgical opportunity and R0 resection rate in patients with advanced cancers. The optimal timing of surgical intervention after neoadjuvant therapy can bring maximum profit for patients. In this article the optimal interval between neoadjuvant therapy and surgical treatment for different digestive tract tumors is reviewed,and its effects on perioperative complications,postoperative pathological remission rate and long-term survival are discussed;and the problems and prospects are also analyzed and summarized.