2010—2019年国家自然科学基金资助合成生物学领域情况

Grant and funding for synthetic biology at NSFC from 2010 to 2019

合成生物学以工程化设计理念,对生物体进行有目标的设计、改造乃至重新合成,是生命科学研究的新兴前沿领域。合成生物学研究的技术方法和工具手段,可能突破生命自然进化的限制,通过新颖的研究思路拓展了对生命现象与规律的认识,有望引领生命科学研究的未来。我国科学家在科学基金的资助下围绕染色体人工合成、基因元件、最小基因组构建等研究前沿取得了系列创新成果。本文梳理了2010—2019年期间,科学基金网络信息系统数据库中,国家自然科学基金委合成生物学相关项目的申请及资助情况、获资助项目的主要研究进展、国际合成生物学领域发展规划与布局。据此,分析科学基金资助合成生物学发展面临的挑战,提出合成生物学项目资助管理工作的建议,为相关科研工作者提供参考。

Synthetic biology is a cutting-edge research field in life science with engineering concepts,targeted design,transformation and even re-construction of organisms.The technical methods and tools of synthetic biology may break through limit of natural evolution for life.It expands the understanding of life phenomena and laws through novel ideas,which is expected to lead the future of life science research.Chinese scientists have made a series of innovative achievements in the frontiers of chromosome synthesis,genetic element buildup,and minimal genome construction with the support of the National Science Foundation of China(NSFC).This article summarizes the application and funding status of synthetic biology projects from 2010 to 2019 based on the NSFC Network Information System database,as well as,the main research progress and international synthetic biology development planning and layout.Accordingly,it analyzes the challenges in funding synthetic biology research by NSFC,and suggests the management of synthetic biology projects,which provides reference for relevant researchers.