磁共振神经突方向离散度与密度成像对帕金森病患者壳核病变的临床应用

Clinical application of magnetic resonance NODDI in the diagnosis of putamen disease in patients with Parkinson's disease

目的探讨磁共振神经突方向离散度与密度成像(neurite orientation dispersion and density imaging,NODDI)对帕金森病患者的临床应用价值。材料与方法收集我院41例帕金森病(Parkinson’s disease)患者和22名年龄和性别匹配的正常志愿者作为对照组进行磁共振平扫和NODDI,量化分析PD患者壳核(putamen)的变化,在组间比较壳核的细胞内体积分数(entracellular volume fraction,Vic)、方向分散指数(orientation dispersion index,ODI)和各向同性体积分数(volume fraction of the isotropic compartment,Viso)。多因素Logistic分析确定PD的独立预测因子。结果PD患者壳核中的Vic、ODI明显低于健康对照组(P<0.05)。多因素Logistic分析显示,PD患者壳核中的Vic值的变化与PD的相关性具有统计学意义(P<0.05),壳核中的Vic值是PD的独立预测因子。在ROC分析中,患者对侧壳核中的Vic显示出最佳的诊断性能。结论NODDI可能有助于诊断PD。

Objective:To investigate the clinical value of neurite orientation dispersion and density imaging(NODDI)in patients with Parkinson's disease(PD).Materials and Methods:MRI plain scan and NODDI imaging were performed in 41 PD patients and 22 age and sex matched normal subjects as control group to quantitatively analyze the changes of the putamen in PD patients with Parkinson's disease.The intracellular volume fraction(Vic),directional dispersion index(ODI)and isotropic volume fraction(Viso)of the putamen were compared between the two groups.Multivariate logistic regression analysis was used to determine the independent predictors of PD.Results:The levels of Vic and ODI in the putamen of patients with PD were significantly lower than those in healthy controls.Multivariate logistic analysis showed that the change of Vic in the putamen of patients with PD was significantly correlated with PD(P<0.05),the putamen was an independent predictor of PD.In the ROC analysis,the Vic in the contralateral putamen showed the best diagnostic performance.Conclusions:NODDI may be helpful in the diagnosis PD.