二甲双胍联合胰岛素治疗老年糖尿病的临床疗效及预后探究

The Clinical Efficacy and Prognosis of Metformin Combined with Insulin in the Treatment of Senile Diabetes

目的探讨老年糖尿病患者行二甲双胍联合胰岛素治疗的临床效果。方法择取该院于2016年1月—2017年1月期间收治的老年糖尿病患者66例,采用回顾性分析回顾治疗数据。66例患者均行胰岛素+二甲双胍处理,记录治疗前后的血糖、血脂、体质量等指标和不良反应发生情况。结果治疗后FBG、2 hPG以及HbA1c水平相对比于治疗前有所下降,组间对比差异有统计学意义(P<0.05);TG、TC以及LDL-C水平显著降低,HDL-C以及BMI和体质量治疗前后对比差异无统计学意义(P>0.05);患者无胰岛素过敏,注射位置红肿和感染以及水肿情况、低血糖发生率为6.06%、胃部不适24.24%,经过处理后均得到调节。结论胰岛素联合二甲双胍应用于老年糖尿病治疗中,其血糖,血脂等指标有所改善,体质量增加无变化,证实预后有效性。

Objective To explore the clinical effect of metformin combined with insulin therapy in elderly diabetic patients.Methods A total of 66 elderly diabetic patients admitted in the hospital from January 2016 to January 2017 were selected,and the treatment data was review by retrospective analysis.All 66 patients were treated with insulin and metformin,and the blood glucose,blood lipid,body mass and other indicators and adverse reactions were recorded before and after treatment.Results After treatment,the levels of FBG,2 hPG and HbA1c decreased compared with before treatment,and the comparison between the groups was statistically significant difference(P<0.05);TG,TC and LDL-C levels were significantly reduced,HDL-C and BMI and body had no difference statistically significant difference in quality before and after treatment(P>0.05);the patient had no insulin allergy,redness and infection and edema at the injection site,the incidence of hypoglycemia was 6.06%,and the stomach discomfort was 24.24%,which were all adjusted after treatment.Conclusion Insulin combined with metformin is used in the treatment of senile diabetes,its blood glucose,blood lipids and other indicators have improved,and there is no change in body weight increase,confirming the prognostic effectiveness.