中国人群帕金森病发病相关因素Meta分析

Related factors for Parkinson′s disease in Chinese population:a Meta analysis

目的探讨中国人群帕金森病发病的相关因素。方法通过中国生物医学文献数据库、万方数据库、维普数据库、中国知网、PubMed等收集1993—2019年发表的关于帕金森病发病危险因素的相关文献,运用STATA11.0中Meta-analysis模块对文献进行统计分析。结果共纳入15篇文献。吸烟(OR=0.58,95%CI:0.53~0.62)、喝茶(OR=0.12,95%CI:0.07~0.16)、饮酒(OR=0.70,95%CI:0.46~0.93)、饮用井水(OR=0.33,95%CI:0.17~0.49)为帕金森病的保护因素,家族史(OR=5.13,95%CI:1.73~8.52)、接触杀虫剂(OR=2.89,95%CI:1.66~4.12)、重大精神创伤(OR=3.28,95%CI:1.69~4.86)是帕金森病的危险因素,而抑郁(OR=3.38,95%CI:0.50~6.26)与帕金森病无明显相关性。结论吸烟、喝茶、饮酒、饮用井水为帕金森病的保护因素,家族史、接触杀虫剂、重大精神创伤是帕金森病发病的危险因素,而抑郁尚不能视为帕金森病发病的相关因素。

Objective To study the related factors for Parkinson′s disease(PD)in Chinese population.Methods The related literature on PD published during 1993-2019 were retrieved from China Biomedical Document Database(CBM),Wangfang Data,VIP Database for Chinese Technical Periodicals(VIP),China Knowledge Resource Integrated Database(CNKI)and PubMed.The included literatures were statistically analyzed by using the Meta analysis module in the STATA11.0.Results Fifteen articles were included.Smoking(OR=0.58,95%CI:0.53-0.62),drinking tea(OR=0.12,95%CI:0.07-0.16),alcohol drinking(OR=0.70,95%CI:0.46-0.93),and drinking well water(OR=0.33,95%CI:0.17-0.49)were the protective factors of PD.The family history(OR=5.13,95%CI:1.73-8.52),contacting insecticide(OR=2.89,95%CI:1.66-4.12),major psychological trauma(OR=3.28,95%CI:1.69-4.86)were the risk factors of PD,whlie the depression(OR=3.38,95%CI:0.50-6.26)had no obvious correlation with PD.Conclusion Smoking,drinking tea,alcohol drinking and drinking well water are the protective factors of PD.The family history,contacting insecticide,major psychological trauma are the risk factors of PD,but the depression has not been considered as a related factor for PD.