缩宫素联合欣母沛预防剖宫产术后出血临床评价

Oxytocin Combined with Hemabate in Preventing Bleeding After Cesarean Section

目的探讨缩宫素联合欣母沛预防剖宫产术后出血的临床疗效。方法选取长江航运总医院2016年3月至2018年3月收治拟行剖宫产的产妇80例,按随机数字表法分为观察组和对照组,各40例。两组产妇术中均深度肌肉注射缩宫素注射液,观察组产妇加用卡前列素氨丁三醇注射液(商品名欣母沛)深度肌肉注射。结果观察组总有效率为95.00%,显著高于对照组的72.50%(P<0.05);观察组产妇术后2,24 h的出血量均显著少于对照组,出血率显著低于对照组(P<0.05);术后,观察组产妇的D-二聚体及纤维蛋白原水平均显著低于对照组,子宫壁、子宫前壁、子宫后壁厚度均显著大于对照组(P<0.05);观察组与对照组不良反应发生率相当(χ^2=0.157,P>0.05)。结论缩宫素联合欣母沛用于剖宫产术中能有效减少术后出血量,增加子宫肌层厚度。

Objective To explore the clinical efficacy of oxytocin combined with hemabate in preventing bleeding after cesarean section.Methods A total of 80 pregnant women admitted to the hospital for cesarean section from March 2016 to March 2018 were selected and divided into the observation group and control group by random number table method,40 cases in each group.Both groups were treated with intravenous drip of oxytocin injection,while the observation group was additionally given intramuscular carboprost tromethamine injection(hemabate).Results The total effective rate of the observation group was 95.00%,which was significantly higher than 72.50%in the control group(P<0.05);the bleeding volume of the observation group was significantly less than that of the control group at 2,24 h after operation,and the bleeding rate was significantly lower than that of the control group(P<0.05);the levels of D-dimer(D-D)and fibrinogen(Fib)were significantly lower than those of the control group,and the thickness of the uterine wall,anterior uterine wall,and posterior uterine wall were significantly greater than those of the control group(P<0.05);the incidence of adverse reactions in the observation group and the control group were equal(χ^2=0.157,P>0.05).Conclusion Oxytocin combined with hemabate in preventing bleeding in cesarean section can effectively reduce postoperative blood loss and increase myometrium thickness.