高压氧联合呼吸肌训练对脑卒中患者呼吸功能及生活质量的影响

Effect of hyperbaric oxygen combined with respiratory muscle training on respiratory function and quality of life in stroke patients

目的分析高压氧联合呼吸肌训练对脑卒中患者呼吸功能及生活质量的影响。方法选取2016年5月至2019年1月烟台山医院神经内科收治的脑卒中患者100例为研究对象,按照随机数字表法将患者分为联合组(50例)和对照组(50例),联合组给予高压氧联合呼吸肌训练,对照组仅给予呼吸肌训练治疗,比较2组临床疗效、呼吸功能、动脉血气分析指标、生活质量及不良反应。结果联合组经高压氧联合呼吸肌训练治疗后临床总有效率为82.00%,明显高于对照组的60.00%,差异有统计学意义(P<0.05);治疗后2组的用力肺活量(forced vital capacity,FVC)、第1 s用力呼吸容积(forced experatory volume in 1 s,FEV1)占预计值百分比、最大通气量(maximum ventilation,MVV)占预计值百分比均较治疗前明显升高,且联合组明显高于对照组,差异具有统计学意义(均P<0.01);治疗后2组患者动脉血氧分压(arterial oxygen partial pressure,PaO2)、动脉血压饱和度(arterial oxygen saturation,SaO2)、氧合指数(oxygenation index,OI)均较治疗前明显升高,且联合组明显高于对照组,差异有统计学意义(均P<0.01),治疗后2组乳酸(lactic acid,Lac)水平均较治疗前明显降低,且联合组明显低于对照组,差异有统计学意义(均P<0.01)。治疗后2组患者生活质量指数(quality of life index,QL-Index)评分均较治疗前明显升高,且联合组明显高于对照组,差异具有统计学意义(均P<0.01);2组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论高压氧联合呼吸肌训练治疗脑卒中患者可及早促进患者康复,提高呼吸功能,明显改善日常生活质量,该联合疗法值得临床推广使用。

Objective To analyze the effects of hyperbaric oxygen combined with respiratory muscle training on respiratory function and quality of life in stroke patients.Methods A total of 100 stroke patients admitted to the Department of Neurology of Yantai Mountain Hospital from May 2016 to January 2019 were selected as the research objects.According to the method of random number table,the patients were divided into the combined group(50 cases)and the control group(50 cases).The combined group was given hyperbaric oxygen combined with respiratory muscle training,and the control group was only given respiratory muscle training.The clinical efficacy,respiratory function,arterial blood gas analysis index,quality of life,and adverse reactions were compared between the two groups.Results The total clinical effective rate of the combined group after hyperbaric oxygen combined with respiratory muscle training was 82.00%,which was significantly higher than that(60.00%)of the control group(P<0.05).After treatment,the forced vital capacity(FVC),forced expiratory volume in 1 s(FEV1),and maximum ventilation volume(MVV)of the two groups were significantly higher than those before treatment(P<0.01);furthermore,those of the combined group were significantly higher than those of the control group,and the differences were statistically significant(P<0.01).After treatment,arterial oxygen partial pressure(PaO2),arterial oxygen saturation(SaO2),and oxygenation index(OI)of the two groups were all significantly higher than those before treatment(P<0.05),and those of the combined group were significantly higher than those of the control group(P<0.01);the lactic acid(Lac)levels in both groups were significantly lower than those before treatment,and the Lac level in the combined group was significantly lower than that in the control group(P<0.01).After treatment,The quality of life index(QL-Index)scores of the two groups were significantly higher than those before treatment(P<0.05),and those of the combined group were significantly higher than those of the control group,and the differences were statistically significant(P<0.01).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Hyperbaric oxygen combined with respiratory muscle training in the treatment of stroke patients can promote early rehabilitation of the patients,improve respiratory function,and significantly improve their quality of daily life,and thus this therapy is worthy of popularization and application in clinic.