强力定眩片联合氟桂利嗪治疗脑动脉硬化性眩晕的疗效观察

Clinical observation of Qiangli Dingxuan Tablets combined with flunarizine in treatment of cerebral arteriosclerotic vertigo

目的探讨强力定眩片联合氟桂利嗪治疗脑动脉硬化性眩晕的临床疗效。方法选取2017年3月—2019年12月天津市宁河区医院收治的脑动脉硬化性眩晕患者120例,随机分为对照组(60例)和治疗组(60例)。对照组口服盐酸氟桂利嗪胶囊,65岁以下患者10 mg/次,65岁以上患者5 mg/次,1次/d,每周给药5 d。治疗组在对照组的基础上口服强力定眩片,4片/次,3次/d。两组均治疗2个月。观察两组患者临床疗效,同时比较治疗前后两组患者症状评分,及右椎动脉、左椎动脉和基底动脉的平均血流速度。结果治疗后,对照组临床有效率为76.67%,显著低于治疗组的91.67%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者植物神经功能紊乱、听力障碍、眩晕、平衡障碍、头痛、耳鸣症状评分均明显下降(P<0.05),且治疗组明显低于对照组(P<0.05)。治疗后,两组患者右椎动脉、左椎动脉和基底动脉的平均血流速度均显著升高(P<0.05),且治疗组明显高于对照组(P<0.05)。结论强力定眩片联合氟桂利嗪治疗脑动脉硬化性眩晕,可迅速改善患者临床症状及脑血流状况,具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Qiangli Dingxuan Tablets combined with flunarizine in treatment of cerebral arteriosclerotic vertigo.Methods Patients(120 cases)with cerebral arteriosclerotic vertigo in Tianjin Ninghe Hospital from March 2017 to December 2019 were randomly divided into control(60 cases)and treatment(60 cases)groups.Patients in the control group were po administered with Flunarizine Hydrochloride Capsules,10 mg/time for less than 65 years old,and 5 mg/time for more than 65 years,once daily,5 times/weekly.Patients in the treatment group were po administered with Qiangli Dingxuan Tablets on the basis of the control group,4 tablets/time,three times daily.Patients in two groups were treated for 2 months.After treatment,the clinical efficacy was evaluated,and the symptom scores,and the mean flow velocity of the right vertebral artery,left vertebral artery and basilar artery in two groups before and after treatment were compared.Results After treatment,the clinical efficacy in the control group was 76.67%,which was significantly lower than 91.67%in the treatment group,and there were differences between two groups(P<0.05).After treatment,the symptom scores of dysfunction of the vegetative nerve,hearing impairment,vertigo,balance disorders,headache and tinnitus in two groups were significantly decreased(P<0.05),and these scores in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,the mean flow velocity of the right vertebral artery,left vertebral artery and basilar artery in two groups was significantly increased(P<0.05),and which in the treatment group was significantly higher than that in the control group(P<0.05).Conclusion Qiangli Dingxuan Tablets combined with flunarizine in treatment of cerebral arteriosclerotic vertigo can rapidly improve the clinical symptoms and cerebral blood flow,which has a certain clinical application value.