三拗片联合特布他林治疗咳嗽变异性哮喘的临床研究

Clinical study on San’ao Tablets combined with terbutaline in the treatment of cough variant asthma

目的探讨三拗片联合特布他林治疗咳嗽变异性哮喘的临床研究。方法选取2019年8月—2020年4月在青岛西海岸新区中医医院门诊急诊治疗的咳嗽变异性哮喘患者90例,随机分为对照组(n=45)和治疗组(n=45)。对照组经雾化器吸入硫酸特布他林雾化液,2.5 mg/次,3次/d;治疗组在对照组治疗的基础上口服三拗片,2片/次,3次/d。两组均连续治疗14 d。观察两组的临床疗效,比较两组咳嗽症状的缓解和消失时间。比较两组嗜酸性粒细胞和肺功能的变化情况。结果治疗后,治疗组的总有效率95.56%,显著高于对照组的73.33%(P<0.05)。治疗后,治疗组咳嗽缓解时间和咳嗽消失时间明显短于对照组(P<0.05)。治疗后,两组患者血清中嗜酸性粒细胞水平明显低于治疗前水平(P<0.05);治疗组治疗后血清中嗜酸性粒细胞水平显著低于对照组(P<0.05)。治疗后,两组患者肺活量(FVC)、第1秒用力呼气量(FEV1)和最大呼气流量(PEF)明显高于治疗前(P<0.05);治疗组治疗后FVC、FEV1和PEF显著高于对照组(P<0.05)。结论三拗片联合特布他林治疗咳嗽变异性哮喘具有较好的临床疗效,能降低嗜酸性粒细胞水平,有效改善临床症状和肺功能指标,具有一定的临床推广应用价值。

Objective To study the clinical effect of San’ao Tablets combined with terbutaline in the treatment of cough variant asthma.Methods A total of 90 patients with cough variant asthma admitted to West Coast New District Hospital of Traditional Chinese Medicine outpatient and emergency from August 2019 to April 2020 were randomly divided into control group(n=45)and treatment group(n=45).The control group inhaled Terbutaline Sulphate Solution for Nebulization,2.5 mg/time,three times daily.The treatment group was po administered with San’ao Tablets on the basis of the control group,2 tablets/time,three times daily.All patients were treated for 14 days.The clinical efficacy of the two groups was observed,and the relief and disappearance time of cough symptoms in the two groups was compared.The changes of eosinophils and lung functions were compared between the two groups.Results The total effective rate in the treatment group was 95.56%,which was significantly higher than 73.33%in the control group(P<0.05).After treatment,the remission time and disappearance time of cough in the treatment group were significantly shorter than those in the control group(P<0.05).After treatment,the serum level of eosinophils in both groups was significantly lower than that before treatment(P<0.05).The serum level of eosinophils in the treatment group was significantly lower than that in the control group(P<0.05).After treatment,vital capacity(FVC),forced expiratory capacity(FEV1)and maximum expiratory flow(PEF)in the two groups were significantly higher than those before treatment(P<0.05).After treatment,FVC,FEV1 and PEF in the treatment group were significantly higher than those in the control group(P<0.05).Conclusion San’ao Tablets combined with terbutaline has good clinical effect in the treatment of cough variant asthma,and can reduce eosinophil levels,also can effectively improve clinical symptoms and lung function indicators,which has a certain clinical application value.