摘要
目的探讨蛤蚧定喘丸联合多索茶碱片治疗对支气管哮喘的临床效果。方法选取开封市中医院2018年3月—2019年6月收治的支气管哮喘患者94例,随机分为对照组和治疗组,每组各47例。对照组饭前或饭后3 h口服多索茶碱片,0.4 g/次,2次/d;治疗组在对照组的基础上口服蛤蚧定喘丸,6 g/次,2次/d。两组患者均治疗12周。观察两组患者临床疗效,同时比较治疗前后两组患者肺功能指标第1秒用力呼气容积量(FEV1)、或最大呼气峰流速(PEF)、用力呼气肺活量(FVC)和第1秒用力呼气容积率(FEV1%),及炎性因子高敏C反应蛋白(hs-CRP)、γ干扰素(INF-γ)和嗜酸性粒细胞(EOS)水平。结果治疗后,对照组和治疗组临床有效率分别为80.85%和95.74%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者肺功能指标FVC、PEF、FEV1、FEV1%比治疗前均明显提高(P<0.05),且治疗组明显高于对照组(P<0.05)。治疗后,两组患者炎性因子hs-CRP、EOS、INF-γ水平均明显降低(P<0.05),且治疗组明显低于对照组(P<0.05)。结论蛤蚧定喘丸联合多索茶碱片治疗支气管哮喘患者疗效显著,可显著改善患者的肺功能,降低炎症因子水平。
Objective To explore the clinical effect of Gejie Dingchuan Pills combined with doxofylline in treatment of bronchial asthma.Methods Patients(94 cases)with bronchial asthma in Kaifeng Hospital of TCM from March 2018 to June 2019 were randomly divided into control and treatment groups,and each had 47 cases.Patients in the control group were po administered with Doxofylline Tablets 3 h before or after meals,0.4 g/time,twice daily.Patients in the treatment group were po administered with Gejie Dingchuan Pills on the basis of the control group,6 g/time,twice daily.Patients in two groups were treated for 12 weeks.After treatment,the clinical efficacy was evaluated,and the lung function indexes of FEV1,PEF,FVC and FEV1%,and the levels of hs-CRP,EOS,NF-γin two groups before and after treatment were compared.Results After treatment,the clinical efficacy and in the control and treatment groups was 80.85%and 95.74%,respectively,and there were differences between two groups(P<0.05).After treatment,the lung function indexes levels of FEV1,PEF,FVC and FEV1%in two groups were significantly increased(P<0.05),and these indexes in the treatment group were significantly higher than those in the control group(P<0.05).After treatment,the levels of hs-CRP,EOS,INF-γin two groups were significantly decreased(P<0.05),and these inflammatory factor levels in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Gejie Dingchuan Pills combined with doxofylline has significant curative effect in treatment of bronchial asthma,can significantly improve the lung function and reduce the level of inflammatory factors.
作者
武改
韩圣宾
WU Gai;HAN Shen-bin(Department of Pharmacy,Kaifeng Hospital of TCM,Kaifeng 475000,China;Department of Pulmonary Disease,Kaifeng Hospital of TCM,Kaifeng 475000,China)
出处
《现代药物与临床》
CAS
2020年第8期1647-1650,共4页
Drugs & Clinic