摘要
在泌尿系肿瘤的常规治疗手段中,化疗药物的毒副作用和多药耐药的发生以及手术后复发率高等弊端,迫切需要开发出治疗泌尿系肿瘤新型有效的策略。纳米技术作为一门新兴且跨学科的领域,因其可改善药动学、优化药物靶向性、提高生物相容性等独特优势被寄望于肿瘤的预防和诊疗上。主要就近年来纳米载药系统在泌尿系肿瘤中的研究进展进行全面、系统的综述。
In the conventional treatment of urinary tumors,chemotherapeutic drugs had the side effects and the occurrence of multidrug resistance,as well as the high recurrence rate after operation,therefore new and effective treatment strategies are forced to be developed.As a new and interdisciplinary field,nanotechnology is expected to be used in tumor prevention and treatment because of its unique advantages,such as improving pharmacokinetics,optimizing drug targeting,improving biocompatibility and so on.The latest application of nano-drug loading system in urinary tumors in recent years is reviewed comprehensively and systematacially in this paper.
作者
李林峰
高漓
LI Lin-feng;GAO Li(Guilin Medical College,Guilin 541001,China)
出处
《现代药物与临床》
CAS
2020年第8期1724-1728,共5页
Drugs & Clinic
基金
国家自然科学基金资助项目(81660425)
广西自然科学基金资助项目(2019GXNSFAA185034)
桂林市科学研究与技术开发计划课题资助项目(20170226)。
关键词
纳米药物递送系统
前列腺癌
膀胱癌
肾癌
主动靶向
nano-drug delivery system
prostate cancer
bladder cancer
renal cancer
active targeting
