子宫内膜癌组织KIF23、LAPTM4B、Snail表达与患者临床病理参数及预后的关系

Expression of KIF23,LAPTM4B,Snail in Endometrial Carcinoma and Their Relationship with Clinicopathological Parameters and Prognosis

目的:探讨子宫内膜癌组织驱动蛋白家族成员23(KIF23)、溶酶体相关4次跨膜蛋白质β(LAPTM4B)、Snail表达与患者临床病理参数及预后的关系。方法:选择2012年10月至2015年2月期间在我院治疗的130例子宫内膜癌患者进行临床研究,采用免疫组织化学染色法检测KIF23、LAPTM4B、Snail的表达,分析KIF23、LAPTM4B、Snail的表达与各项临床病理参数及预后的关系。Cox比例风险回归分析子宫内膜癌患者预后的影响因素。结果:子宫内膜癌组织中KIF23、LAPTM4B、Snail阳性率明显高于癌旁正常组织(x^2=61.356、67.031、82.028,均P=0.000)。子宫内膜癌组织中KIF23、LAPTM4B、Snail表达与淋巴结转移、肌层浸润和FIGO分期相关(P<0.05)。KIF23、LAPTM4B、Snail阳性患者5年总生存率明显低于KIF23、LAPTM4B、Snail阴性患者(P<0.05)。FIGO分期、KIF23、LAPTM4B和Snail是子宫内膜癌患者预后的影响因素(HR=1.409、1.478、1.523、2.178,P<0.05)。结论:KIF23、LAPTM4B和Snail在子宫内膜癌中阳性表达率升高,并且均与子宫内膜癌淋巴结转移、肌层浸润、FIGO分期和预后相关,在子宫内膜癌的诊断和预后评估中具有一定临床意义。

Objective:To explore the relationship between the expression of kinesin family member 23(KIF23),lysosome-associated protein transmembrane 4 beta(LAPTM4B),Snail and the clinicopathological parameters and prognosis of patients with endometrial carcinoma.Methods:130 cases of patients with endometrial carcinoma who were treated in our hospital from October 2012 to February2015 were selected for clinical study.The expressions of KIF23,LAPTM4B and Snail were detected by immunohistochemical staining,and the relationship between the expressions of KIF23,LAPTM4B and Snail and various clinicopathological parameters and prognosis were analyzed.Cox proportional risk regression was used to analyze the prognostic factors of patients with endometrial carcinoma.Results:The positive rates of KIF23,LAPTM4B and Snail in endometrial carcinoma tissues were significantly higher than those in adjacent normal tissues(x^2=61.356,67.031,82.028;all P=0.000).The expression of KIF23,LAPTM4B and Snail were associated with lymph node metastasis,muscle infiltration and FIGO stage in endometrial carcinoma(P<0.05).The 5-year overall survival rate of KIF23,LAPTM4B and Snail positive patients were significantly lower than that of KIF23,LAPTM4B and Snail negative patients(P<0.05).FIGO stage,KIF23,LAPTM4B and Snail were the prognostic factors for patients with endometrial carcinoma(HR=1.409,1.478,1.523,2.178,P<0.05).Conclusion:KIF23,LAPTM4B and Snail have increased positive rates in endometrial carcinoma,and they are all related to lymph node metastasis,muscle infiltration,FIGO stage and prognosis of endometrial carcinoma,which have certain clinical significance in the diagnosis and prognosis assessment of endometrial carcinoma.