2015-2018年重庆万州区女性HPV的感染状况、基因亚型及年龄分布研究

Study on the Infection Status,Gene Subtype and Age Distribution of Female HPV in Wanzhou District of Chongqing from 2015 to 2018

目的:研究2015-2018年重庆万州区女性人乳头瘤病毒(HPV)的感染状况、基因亚型及年龄分布。方法:选取2015年1月-2018年12月期间重庆万州区进行两癌筛查以及前来我院就诊的女性,共计1203例,采用PCR-反向点杂交法检测HPV感染情况,分析各个年龄段HPV的感染状况、各个年龄段HPV感染基因亚型以及各个年龄段HPV单一感染和多重感染情况。结果:接受HPV检测的1203例女性中共有457例出现HPV感染,感染率为37.99%,其中<30岁35例,感染率为36.84%;30~39岁117例,感染率为37.74%;40~49岁120例,感染率为35.82%;50~59岁127例,感染率为37.46%;≥60岁57例,感染率为45.97%,各个年龄段之间的HPV的感染率比较差异有统计学意义(P<0.05),457例患者中共有635个HPV感染基因,其中高危型感染基因共568个,占感染基因的89.45%,低危型感染基因共67个,占感染基因的10.55%。单一感染人数共333人,占总感染人数的72.87%,其中高危单一感染共301人,占总感染人数65.86%,低危单一感染共32人,占总感染人数7.00%。多重感染人数共124人,占总人数的27.13%。结论:2015-2018年重庆万州区女性HPV感染率为37.99%,其中≥60岁年龄段的女性HPV感染率最高,高危感染和单一感染为主要的感染类型。

Objective:To investigate the infection status,gene subtype and age distribution of female HPV in Wanzhou District of Chongqing area from 2015 to 2018.Methods:A total of 1203 women who were carried out two cancer screening in Wanzhou District of Chongqing and checked in our hospital from January 2015 to December 2018 were selected.HPV infection status were detected by PCR reverse dot blot,and the infection status of HPV in each age group,the subtype of HPV infection gene in each age group,and the HPV single infection and multiple infection in each age group were analyzed.Results:There were 457 cases of HPV infection in 1203 women who were tested by HPV,and the infection rate was 37.99%.Among them,less than 30 years old were 35 cases,and the infection rate was 36.84%,from 30 to 39 years old were 117 cases,the infection rate was 37.74%,from 40 to 49 years old were 120 cases,the infection rate was 35.82%,from 50 to 59 years old were 127 cases,the infection rate was 37.46%,greater than or equal to 60 years old were 57 cases,the infection rate was 45.97%.There was a significant difference in the infection rate of HPV between different ages(P<0.05).There were 635 HPV infection genes in 457 patients,there were 568 high-risk infection genes,accounting for 89.45%of the infection genes,and 67 low-risk infection genes,accounting for 10.55%of the infection genes.The number of single infection was 333 people,accounting for 72.87%of the total infection.Among them,there were 301 people with high-risk single infection,accounting for 65.86%of the total infection,and there were 32 people with low-risk single infection,accounting for 7.00%of the total infection,the number of multiple infections was 124 people,accounting for 27.13%of the total infection.Conclusion:The infection rate of HPV infection in women in Wanzhou District of Chongqing from 2015 to 2018 was 37.99%,and the highest rate of HPV infection is in women with age≥60 years old,high-risk infection and single infection are the main types of infection.