高速逆流色谱仪行星架结构设计与拓扑优化

Structure Design and Topology Optimization of Planet Carrier of High Speed Countercurrent Chromatograph

高速逆流色谱技术在解决生物医药领域活性成分分离纯化的瓶颈问题上具有无不可逆吸附、样品回收率高、耐受性好等独特优势,因此十分有必要提升现有小型高速逆流色谱仪的分离纯化效能,开发具有高效、快速、大容量制备能力的工业型高速逆流色谱仪。作者以大容量高速逆流色谱仪的行星架结构为研究对象,首先在3维软件中设计行星架结构,并以仿真软件HyperWorks为平台,建立有限元模型,根据行星架上主要负载的受力特点施加载荷及约束条件,进行了静力学分析及模态分析,发现其最大变形和最大等效应力都较小,1阶模态频率较高,可进一步优化结构。基于变密度法中的SIMP(solid isotropicmaterial with penalization)插值模型,利用折衷规划法建立了提高刚度并减小柔度的多目标函数的数学模型,对行星架进行结构拓扑优化,寻求材料更合理分布,并得到了优化结构。在优化结果的基础上重新设计了新行星架,再次进行动静力学性能仿真分析,确保行星架结构改进设计的合理性。研究表明:仿真分析结果验证了结构的安全可靠性,优化后的行星架的各项性能都能满足要求,并且质量降低了13.1%,得到了比原始结构更加优良的新结构。

High speed countercurrent chromatography has unique advantages in resolving the bottleneck of separation and purification of active ingredients in the field of biomedicine,such as no irreversible adsorption,high sample recovery and good tolerance.Therefore,it is necessary to improve the separation and purification efficiency of the existing small high speed countercurrent chromatograph and develop an industrial high speed countercurrent chromatograph with high efficiency,fast and large capacity.The structure of planet carrier of large-capacity high speed countercurrent chromatograph was taken as the research object.Firstly,the three-dimensional structure of the planet carrier was designed in the software.Secondly,the finite element model was established on the platform of hyperWorks.Static analysis and modal analysis were carried out by applying loads and constraint conditions on the planetary frame according to the characteristics of forces.It was found that the maximum deformation and maximum equivalent stress are both small,and the first order natural frequency is high.The structure can be further optimized.Based on the SIMP interpolation model of variable density method,a mathematical model of multi-objective function for improving stiffness and reducing flexibility was established by using compromise programming method.The structural topology optimization of the planet carrier was carried out,the material distribution was more reasonable,and the optimized structure was obtained.Based on the optimization results,the new planet carrier was redesigned,the dynamic and static simulation analysis was carried out again to ensure the rationality of the improved design of planet carrier structure.The research showsed that results of simulation analysis validate the safety and reliability of the structure.The optimized planet carrier can meet the requirements in various performances,and the quality was reduced by 13.1%.A new structure that is superior to the original structure was obtained.