晶状体功能失调指数与视力、晶状体混浊程度相关性分析

Analysis of correlations between lens dysfunction index and LogMAR Visual Acuity and LOCS Ⅲ grading criteria in age-related cataract patients

目的探究晶状体功能失调指数(DLI)与年龄相关性白内障患者LogMAR视力、晶状体混浊程度分级系统Ⅲ(LOCSⅢ)分级评分的相关性。方法纳入年龄相关性白内障患者48例(96只眼)组成白内障组。另随机选取同期就诊于沧州眼科医院的同年龄段健康体检者40例(80只眼)组成健康组。观察指标有LogMAR视力,晶状体混浊程度(LOCSⅢ分级体系判断并评分),晶状体功能失调指数DLI值(采用iTrace视功能分析仪测量)。结果(1)白内障组患者LogMAR视力(t=23.326,P=0.000)、LOCⅢ分级晶状体核的混浊程度(NO)评分(t=32.427,P=0.000)、LOCⅢ分级晶状体核的颜色(NC)评分(t=27.987,P=0.000)均高于健康组,均有统计学意义;白内障组DLI值低于健康组(t=32.453,P=0.000),差异有统计学意义;(2)年龄相关性白内障患者DLI与LogMAR视力(r=-0.626,P=0.000)、LOCSⅢ-NO评分(r=-0.516,P=0.000)、LOCSⅢ-NC评分(r=-0.495,P=0.000)均呈负相关;LogMAR视力(t=6.834,P=0.005)、LOCSⅢ-NO评分(t=7.002,P=0.004)、LOCSⅢ-NC评分(t=6.491,P=0.006)是年龄相关性白内障患者DLI值的密切相关因素;DLI对年龄相关性白内障患者诊断的曲线下面积(AUC)为0.857。结论年龄相关性白内障患者DLI与LogMAR视力、LOCSⅢ分级评分呈负相关,DLI对年龄相关性白内障有诊断价值,值得临床筛选借鉴。

OBJECTIVE To explore the correlation between the lens dysfunction index(DLI with the LogMAR vision and lens opacities classification system(LOCS Ⅲ) in age-related cataract patients. METHODS 96 eyes of 48 age-related cataract patients who met the inclusion criteria were selected as the study group. In addition, 40 age-matched healthy people(80 eyes) who were admitted to Cangzhou Ophthalmological Hospital were randomly selected as the control group. The LogMAR vision was examined in both groups, according to LOCS Ⅲ classification system, the degree of lens opacity was judged and scored. The DLI value was measured by i Trace visual function analyzer. RESULTS(1) LogMAR visual acuity(t=23.326, P=0.000), LOCSⅢ-NO scores(t=32.427,P =0.000) and LOCS Ⅲ-NC scores(t =27.987,P =0.000) in the research group were significantly higher than those in the control group;the DLI scores of the research group were significantly lower than that of the control group(t=32.453, P=0.000);(2) The DLI in age-related cataract patients was negatively correlated with LogMAR visual acuity(r=-0.626, P=0.000), LOCS Ⅲ-NO scores(r=-0.516,P=0.000) and LOCS Ⅲ-NC scores(r=-0.495, P=0.000)in age-related cataract patients;(3) LogMAR visual acuity(t=6.834, P =0.005), LOCS Ⅲ-NO scores(t=7.002, P=0.004) and LOCS Ⅲ-NC scores(t=6.491, P=0.006) were closely related factors of DLI in age-related cataract patients.(4) The diagnostic AUC of DLI for age-related cataract patients was 0.857. CONCLUSION The DLI is negatively correlated with LogMAR visual acuity and LOCS Ⅲ grading scores in age-related cataract patients, DLI has diagnostic value for senile cataract and is worthy promoting in clinical screening.