眼睑痉挛型Meige综合征中西医研究进展

Research progress on blepharospasm type of Meige syndrome by Chinese and Western Medicine

Meige综合征是一种肌张力障碍性疾病,眼睑痉挛为其最常见的首发症状,以眼轮匝肌渐进性、无规律性、不自主收缩为主要特征,严重者可引起双眼完全闭合,导致功能性失明。目前该病病因及病理机制尚不明确,起病隐匿,症状不典型,临床中亦缺乏客观、特异性的辅助检查手段,早期误诊率较高,且病情易反复,治疗棘手。中西医在本病治疗上各有优势和缺陷,本文综合近年来国内外研究情况,就其发病机制、治疗方法进行总结概述,以提高临床眼科医师对本病的认识。同时,希望通过中西医结合综合疗法,提高病愈率,改善患者生活质量。

Meige syndrome is a muscular dystonia disease. Blepharospasm is the most common first symptom of Meige syndrome. It is characterized by progressive, irregular and involuntary contraction of the orbicularis oculi muscle. In severe cases, it can cause complete closure of the eyes, resulting in functional blindness. At present, the etiology and pathological mechanism of this disease are still unclear with insidious onset and atypical symptoms. Besides, there is also a lack of objective and specific auxiliary examination means to make a clear diagnosis in clinical practice.The early misdiagnosis rate is high, and the condition tends to relapse, and management can be tricky. Both Chinese and Western medicine have their own advantages and disadvantages in the treatment of this disease. This paper summarized the domestic and foreign researches and the pathogenesis and treatment methods of the disease in recent years in order to improve the understanding of clinical ophthalmologists about this disease. Meanwhile, the author expected to improve the recovery rate and patients’ quality of life through the integrated treatment of Chinese and Western Medicine.