小剂量利尿剂治疗慢性心力衰竭的疗效观察

Effect of Low-dose Diuretics in the Treatment of chronic Heart Failure

目的探讨小剂量利尿剂治疗慢性心力衰竭的疗效。方法选择叶县人民医院2016年1月—2018年1月收治的124例慢性心力衰竭患者作为研究对象,采用随机数字法将其分为两组,每组62例。对照组患者采用大剂量利尿剂治疗,观察组患者采用小剂量利尿剂治疗,比较两组患者的治疗效果。结果观察组患者的显效率是75.81%,有效率是100.00%,显著高于对照组的50.00%、88.71%,差异显著(P<0.05);观察组患者治疗后电解质紊乱的发生率为30.65%,低于对照组的50.00%,差异显著(P<0.05);观察组患者不良反应的发生率为6.45%,低于对照组的20.97%,差异显著(P<0.05);观察组患者复发再入院率为6.45%,显著低于对照组的19.35%,差异显著(P<0.05)。结论小剂量利尿剂治疗慢性心力衰竭患者的效果更优,可显著减少患者电解质紊乱的发生情况,降低治疗期间不良反应的发生率和复发再入院率,安全性好,实用性强,可临床应用。

Objective To investigate the effect of low-dose diuretics in the treatment of chronic heart failure.Methods A total of 124 patients with chronic heart failure(CHF)admitted to Ye County people’s hospital from January 2016 to January 2018 were randomly divided into two groups with 62 cases in each group.The patients in the control group were treated with high-dose diuretics,and the patients in the observation group were treated with low-dose diuretics.The therapeutic effects of the two groups were compared.Results The effective rate was 75.81%,and the effective rate was 100.00%in the observation group,which was significantly higher than that of the control group(50.00%,85.48%,P<0.05).The incidence of electrolyte disorder in the observation group was 30.65%,which was lower than that of the control group(50.00%),the incidence of adverse reactions in the observation group was 6.45%,which was lower than that in the control group(20.97%,P<0.05),and the rate of recurrent readmission in the observation group was 6.45%,which was significantly lower than that in the control group(19.35%,P<0.05).Conclusion Low-dose diuretics are more effective in the treatment of patients with chronic heart failure,can significantly reduce the occurrence of electrolyte disorders,reduce the incidence of adverse reactions during treatment and re-admission rate,with good safety and practicality,it can be used in clinical practice.