轻度认知损害的微小RNA差异表达及与阿尔茨海默病和血管性痴呆的相关性研究

Differential Expression of mi RNA in Mild Cognitive Impairment and Its Correlation with Alzheimer’s Disease and Vascular Dementia

轻度认知损害(MCI)是介于正常认知和痴呆之间的中间状态,患有MCI的个体具有更高的转变为痴呆的风险。阿尔茨海默病(AD)和血管性痴呆(VaD)是主要的痴呆类型,在人口老龄化进程不断加速的趋势下,痴呆发病率逐年升高,然而诊断和治疗痴呆仍是临床的一大难题。近年来,分子生物学研究逐渐成为热点,一种短链非编码RNA[微小RNA(miRNA)]因其在生物液体中稳定存在,具有成为痴呆早期诊断的非侵入性生物标记物的潜力。文中就国内外对MCI的miRNA表达与AD和Va D的相关性研究进展作综述。

Mild cognitive impairment(MCI)is a middle stage between normal cognition and dementia,individuals with MCI have a higher risk of developing dementia.Alzheimer’s disease(AD)and vascular dementia(VaD)are the main types of dementia.With the increasing trend of population aging,the incidence of dementia is increasing year by year,and the diagnosis and treatment of dementia is still a major problem.In recent years,the research on molecular biology has gradually become a hot spot.miRNA,a short-chain non-coding RNA,has the potential to be non-invasive biomarker for the early diagnosis of dementia due to its stability in biological fluids.The expression of MCI miRNA and its correlation with AD and VaD at home and abroad are reviewed.