多项肿瘤标志物蛋白芯片检测在胰腺癌诊断中的运用价值分析

Analysis of the value of multiple tumor markers protein chip in the diagnosis of pancreatic cancer

目的探讨多项肿瘤标志物蛋白芯片检测在胰腺癌诊断中的临床运用价值。方法选择2015年6月-2019年6月在本院确诊为胰腺癌的患者50例作为胰腺癌组,并以同期确诊为胰腺良性疾病的50例患者作为胰腺疾病组,50例健康体检者作为对照组,均检测肿瘤标志物水平,并采用肿瘤标志物蛋白芯片技术检测肿瘤标志物。结果胰腺癌组患者CA19-9、CA24-2、CEA、FER、CA125水平均高于胰腺疾病组、对照组。肿瘤标志物CA19-9、CA24-2、CEA、FER、CA125对胰腺癌的阳性率均明显高于胰腺疾病组和对照组(P<0.05)。蛋白芯片技术在胰腺癌患者中灵敏度、特异度、阳性预测值、阴性预测值均为96%。结论蛋白芯片技术在胰腺癌患者中运用有助于提高胰腺癌的诊断效能。

Objective To investigate the clinical value of protein chip assay for multiple tumor markers in the diagnosis of pancreatic cancer.Methods A total of 50 patients with pancreatic cancer diagnosed in our hospital from June 2015 to June 2019 were selected as the observation group,50 patients with benign pancreatic diseases diagnosed in the same period were selected as the pancreatic disease group,and 50 healthy people as the control group.The level of tumor markers was detected,and tumor marker protein chip technology was used to detect tumor markers.Results The levels of CA19-9,CA24-2,CEA,FER and CA125 in pancreatic cancer group were significantly higher than those in pancreatic disease group and control group.The positive rates of tumor markers CA19-9,CA24-2,CEA,FER and CA125 for pancreatic cancer were significantly higher than those for pancreatic disease group and control group(P<0.05).The sensitivity,specificity,positive predictive value and negative predictive value of protein chip in pancreatic cancer patients were all 96%.Conclusion Protein chip technology can improve the diagnostic efficiency of pancreatic cancer in patients with pancreatic cancer.