安阳市流感监测结果及年龄组构成分析

Analysis of influenza surveillance results and age group composition in Anyang City

目的分析安阳市2015年-2019年流感监测结果,为流感防控提供科学依据。方法对流感样病例进行real-time RT-PCR检测、利用MDCK细胞或SPF鸡胚分离病毒,并进行统计学分析。结果共获得流感样病例9460例,主要集中在<5岁组,在4个监测年度的占比分别为47.41%、45.97%、47.47%和52.14%。总阳性率为22.25%,阳性率最高的为5岁~14岁组。4个监测年度中,主要流行优势病毒亚型为新甲型H1N1;60岁以下年龄组中,占主导的病毒亚型为新甲型H1N1,≥60岁组中,占主导的病毒亚型为新甲型H1N1和Yamagata。四个监测年度共分离细胞毒株341株,鸡胚毒株62株。结论本研究指出安阳市流感样病例百分比及核酸阳性率在不同年龄组间存在差异,流感病毒亚型在不同年龄分布上存在差异。

Objective To provide early warning for possible influenza through analyzing the results of influenza surveillance in Anyang City during 2015-2019.Methods Real-time RT-PCR was used to detect influenza-like case,MDCK cells or SPF chicken embryos were used to isolate the virus,and statistical analysis was performed.Results A total of 9460 influenza-like cases were obtained,mainly in the<5 years old group,accounting for 47.41%,45.97%,47.47%and 52.14%in the four surveillance years.The total positive rate was 22.25%,and the highest positive rate was observed in the 5-14 years old group.During 2015-2019,the dominant virus subtype was new A H1N1,the dominant virus subtype in the age group under 60 years old was new A H1N1,and new A H1N1 and Yamagata were the dominant subtypes in the≥60 years old group.A total of 341 cell strains and 62 chicken embryo strains were isolated in the four monitoring years.Conclusion It is pointed in our study that ILI percentage and positive rate of nucleic acid are different in different age groups,and influenza virus subtypes were different in different age distribution in Anyang City.