COMT Val158Met基因多态性与抑郁症相关性的Meta分析

Meta-Analysis of the COMT Val158Met Polymorphism in Major Depressive Disorder

目的采用Meta分析的方法评价COMT Val158Met基因多态性与抑郁症的相关性。方法计算机检索中国期刊全文数据库(CNKI)、万方数据资源系统(WanFang Data)、维普中文期刊数据库(VIP)及PubMed数据库,筛选与所研究位点相关的文献,检索时限为自建库至2020年02月,采用stata13.0软件分析数据。结果共纳入15项研究,包括2542名抑郁症患者,2020名对照者。Meta分析结果显示:在没有观察到研究之间的异质性或发表偏倚的情况下,在总体中COMT Val158Met多态性与抑郁症发病风险相关性无统计学意义,但在东亚人中基因型AG和AA与抑郁症发病风险存在显著的相关性(AG+AAvsGG:OR=1.29,95%CI=1.06-1.56,P=0.01)。结论在东亚人中COMT Val158Met基因多态性中AG和AA基因型可能为抑郁症的危险因素。

Objective To evaluate the relationship between COMT Val158 Met polymorp-hism and Depression by meta-analysis. Methods We searched CNKI,WanFang Data,VIP and PubMed by computer to screen literatures related to the loci studied. The retrieval time was from their establishment to February,2020. and stata13.0 software was used to analyze the Data. Results A total of 15 studies involving 2542 MDD patients and 2020 controls were included. The results of meta-analysis showed that,In the absence of heterogeneity or publication bias between studies,There is no significant association between COMTVal158 Met polymorphism and the risk of depression in general,but there is a significant correlation between genotypes AG and AA and the risk of depression in East Asian population(AG+AAvsGG :OR=1.29,95%CI=1.06-1.56,P=0.01). Conclusion AG and AA genotypes are risk factors for depression in East Asian people with COMTVal158 Met gene polymorphism.