血清孤啡肽、瘦素水平与产后抑郁的相关性研究

Correlation Study Between the Levels of Serum Orphanin and Leptin and Postpartum Depression

目的研究血清孤啡肽(NC)、瘦素(LP)水平与产后抑郁的相关性。方法选择2017年12月~2019年12月我院收治的220例产妇作为研究对象,按照爱丁堡产后抑郁量表(EPDS)评分分组,≥10分为抑郁组,<10者为无抑郁组。比较两组的年龄、产次、分娩方式、体重、孕周、新生儿体重、新生儿性别和NC、LP,并用Pearson直线相关法分析NC、LP与产后抑郁的相关性,用多因素Logistic回归分析产后抑郁的危险因素。结果 220例产妇中,98例EPDS≥10分,122例EPDS<10分。两组的产次、分娩方式、孕周、新生儿体重、新生儿性别比较均无统计学差异(P>0.05);抑郁组的年龄、体重显著高于无抑郁组(P<0.05)。抑郁组的NC显著高于无抑郁组,LP显著低于无抑郁组(P<0.05);经Pearson相关分析发现NC与产后抑郁呈正相关,LP与产后抑郁呈负相关(P<0.05);多因素Logistic回归分析发现年龄、体重、NC、LP均是产后抑郁发生的独立危险因素。结论 NC与产后抑郁呈正相关,LP与产后抑郁呈负相关,这提示监测NC、LP水平,可有助于防治产后抑郁。

Objective To study the correlation between the levels of serum orphanin(NC)and leptin(LP) and postpartum depression. Methods A total of 220 pregnant women from December 2017 to December 2019 in our hospital were selected and divided into two groups according to scores of Edinburgh postpartum depression scale(EPDS),EPDS ≥ 10 were set as the depression group,and EPDS <10 were set as the non-depression group. The age,parity,delivery mode,weight,gestational week,neonatal weight,neonatal gender,NC,and LP were compared between the two groups,and the correlation between NC,LP and postpartum depression was analyzed using the Pearson linear correlation method. Multivariate logistic regression was used to analyze. Results 98 cases had EPDS ≥ 10 points,and 122 had EPDS <10 points. There were no significant differences in parity,delivery methods,gestational weeks,neonatal body,and sex of the newborns between the two groups(P> 0.05). The age and weight of the depression group were significantly higher than those of the non-depression group(P<0.05). The NC of the depression group was significantly higher than that of the non-depression group,while the LP was significantly lower than that of the non-depression group(P<0.05). Pearson linear correlation analysis show that NC was positively correlated with postpartum depression,and LP was negatively correlated with postpartum depression(P<0.05). Multivariate logistic regression analysis show that the age,weight,NC,and LP were independent risk factors for postpartum depression. Conclusion NC is positively correlated with postpartum depression,and LP is negatively correlated with postpartum depression,which prompts monitoring of NC and LP levels can help to find postpartum depression.