喹硫平和利培酮对老年脑血管病所致精神障碍患者的疗效

Comparative analysis of the efficacy and safety of quetiapine and risperidone in senile cerebrovascular disease patients with mental disorders

目的比较利培酮与喹硫平对老年脑血管病所导致精神障碍患者的疗效及安全性。方法收集我院在2017.01-2018.12收治的90例老年脑血管疾病所致精神障碍患者作为研究对象,随机分为A组与B组,每组45人。A组给予利培酮治疗,B组给予喹硫平治疗,比较两组的治疗效果及安全性。结果 A组患者临床治疗总有效率80.00%,显著低于B组的91.11%(P<0.05);治疗后两组PSQI评分、PANSS评分均较治疗前明显降低,且B组降低程度高于A组(P<0.05);A组患者不良反应发生率17.78%,高于B组6.67%(P<0.05)。结论喹硫平与利培酮对老年脑血管疾病所致精神障碍患者的疗效均较好,相比之下喹硫平的疗效更好,不良反应更少。

Objective To compare the efficacy and safety of risperidone and quetiapine in the treatment of mental disorders caused by senile cerebrovascular diseases. Methods 90 cerebrovascular diseases patients with mental disorders in our hospital from January 2017 to December 2018 were randomly divided into group A and group B,45 case in each group. Patients in group A was treated with risperidone,while in group B with quetiapine. The effect and safety of the two groups were observed. Results The total effective rate of group A was 80.00%,which was significantly lower than that(91.11%)of group B(P<0.05). After treatment,PSQI score、PANSS score in both groups were significantly lower than those before treatment,and the degree of decrease in group B was higher than that in group A(P<0.05). The incidence of adverse reactions in group A was 17.78%,which was higher than that(6.67%)in group B(P<0.05). Conclusion Both quetiapine and risperidone are effective in the treatment of mental disorders patients caused by senile cerebrovascular diseases. The effect of quetiapine is better with fewer adverse reactions.