氨磺必利在治疗酒精所致精神障碍疾病中的疗效及预后效果观察

Observation of the Therapeutic Effect and Prognostic Effect of Amisulpride in the Treatment of Mental Disorders Caused by Alcohol

目的分析探讨氨磺必利在治疗酒精所致精神障碍疾病中的疗效及预后效果。方法该次以该院在2018年2月—2019年1月收治的84例酒精所致精神障碍疾病患者作为研究的对象,以随机数字表法分成两组,其中对照组42例给予奋乃静治疗,观察组42例则给予氨磺必利治疗,进一步对两组临床治疗效果进行分析评价。结果①在治疗总有效率上,观察组的95.24%,和对照组的73.81%比较显著更高,两组数据差异有统计学意义(χ^2=10.291,P<0.05)。②在阳性症状、阴性症状、精神病理3项PANSS评分方面,治疗前观察组分别为(25.88±4.13)分、(21.56±4.89)分、(33.86±4.12)分,与对照组的(25.90±4.11)分、(21.54±5.00)分、(33.85±4.10)分比较,差异无统计学意义(t=1.293、1.267、1.296,P>0.05);治疗4周后,观察组分别为(12.35±3.61)分、(12.90±2.65)分、(11.87±2.11)分,与对照组的(19.28±2.45)分、(16.87±2.71)分、(16.20±2.13)分均明显低于对照组,两组数据差异有统计学意义(t=7.256、5.283、5.287,P<0.05)。③在用药不良反应总发生率上,观察组为7.14%,与对照组的28.57%比较明显更低,两组数据之间差异有统计学意义(χ^2=12.384,P<0.05)。结论酒精所致精神障碍疾病患者采取氨磺必利治疗的效果显著,预后理想,用药不良反应发生率低。

Objective To analyze the therapeutic effect and prognostic effect of amisulpride in the treatment of alcohol-induced mental disorders.Methods This time,84 cases of alcohol-induced mental disorders treated in the hospital from February 2018 to January 2019 were used as the research object.They were divided into two groups by random number table method,of which 42 cases in the control group were given perphenazine for treatment,42 cases in the observation group were given amisulpride,and the clinical treatment effects of the two groups were further analyzed and evaluated.Results 1.In terms of total treatment efficiency,95.24%of the observation group was significantly higher than 73.81%of the control group.There was statistically significant difference between the two groups of data(χ^2=10.291,P<0.05).2.For the three PANSS scores of positive symptoms,negative symptoms,and psychopathology,the observation group before treatment was(25.88±4.13)points,(21.56±4.89)points,(33.86±4.12)points,and the control group(25.90±4.11)points,(21.54±5.00)points,(33.85±4.10)points were not statistically significantly different(t=1.293,1.267,1.296,P>0.05);after 4 weeks of treatment,the observation group were(12.35±3.61)points,(12.90±2.65)points,(11.87±2.11)points,and(19.28±2.45)points,(16.87±2.71)points,and(16.20±2.13)points of the control group were significantly lower than the control There were statistically significant differences between the two groups(t=7.256,5.283,5.287,P<0.05).3.In the total incidence of adverse drug reactions,the observation group was 7.14%,which was significantly lower than the control group's 28.57%.There was a significant difference between the two groups of data(χ^2=12.384,P<0.05).Conclusion The effect of amisulpride on patients with mental disorders caused by alcohol is significant,the prognosis is ideal,and the incidence of adverse drug reactions is low.