更昔洛韦联合干扰素治疗小儿病毒性脑炎的效果分析

Analysis of the Effect of Ganciclovir Combined with Interferon in the Treatment of Viral Encephalitis in Children

目的对小儿病毒性脑炎患者采用更昔洛韦联合干扰素治疗的临床应用价值进行探究。方法选择2018年4月—2019年4月该院收治的小儿病毒性脑炎患者共计82例作为该次研究的纳入对象,按照随机数字表法的方式,将这些患儿划分为单一用药组和联合用药组,两组均有41例患儿。通过更昔洛韦对单一用药组予以治疗,在此基础之上,联合使用干扰素对联合用药组予以治疗。在治疗完成之后,观察并比较两组患儿的治疗效果。结果单一用药组达到了的总有效率,联合用药组总有效率95.1%明显高于单一用药组的78.0%(χ^2=9.833,P<0.05)。联合用药组在治疗后的头痛(2.0±0.2)d、意识障碍(2.3±0.5)d、发热(3.0±0.4)d、抽搐(3.1±1.1)d消失时间低于单一用药组的(3.7±0.6)d、(4.1±0.6)d、(4.8±0.8)d、(5.8±1.9)d(t=3.621、3.067、3.504、3.825,P<0.05)。联合用药组不良反应发生率(4.9%)低于单一用药组不良反应发生率(7.3%),但比较结果差异无统计学意义(χ^2=0.236,P>0.05)。结论针对小儿病毒性脑炎患儿采用更昔洛韦联合干扰素治疗具有显著的效果,可以有效地改善患儿的临床症状,而且在不良反应方面很安全。

Objective To investigate the clinical application value of ganciclovir combined with interferon in children with viral encephalitis.Methods A total of 82 children with viral encephalitis admitted from April 2018 to April 2019 to the hospital were selected as the subjects of this study.According to the random number table method,these children were divided into a single medication group and a combination medication group,both groups had 41 children.The single-medication group was treated with ganciclovir,and on this basis,interferon was used to treat the combined-medication group.After the treatment is completed,observe and compare the treatment effect of the two groups of children.Results The total effective rate achieved by the single medication group was 95.1%,which was significantly higher than the 78.0%of the single medication group(χ^2=9.833,P<0.05).After treatment,the disappearance time of headache(2.0±0.2)d,disturbance of consciousness(2.3±0.5)d,fever(3.0±0.4)d,convulsions(3.1±1.1)d in the combined medication group was lower than that in the single medication group(3.7±0.6)d,(4.1±0.6)d,(4.8±0.8)d,(5.8±1.9)d(t=3.621,3.067,3.504,3.825,P<0.05).The incidence of adverse reactions in the combination medication group(4.9%)was lower than that in the single medication group(7.3%),but there was no statistically significant difference in the comparison results(χ^2=0.236,P>0.05).Conclusion The treatment of pediatric viral encephalitis with ganciclovir combined with interferon has a significant effect,can effectively improve the clinical symptoms of children,and is safe in terms of adverse reactions.